Details for: OR4F4

Gene ID: 26682

Symbol: OR4F4

Ensembl ID: ENSG00000177693

Description: olfactory receptor family 4 subfamily F member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0691
    Cell Significance Index: 0.8900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0170
    Cell Significance Index: 0.2700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0133
    Cell Significance Index: -0.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0227
    Cell Significance Index: -0.5800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0254
    Cell Significance Index: -0.5100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0318
    Cell Significance Index: -0.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0352
    Cell Significance Index: -0.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0366
    Cell Significance Index: -0.5200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0376
    Cell Significance Index: -0.6400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0411
    Cell Significance Index: -0.3900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0424
    Cell Significance Index: -0.5000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0434
    Cell Significance Index: -0.5700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0438
    Cell Significance Index: -0.4800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0471
    Cell Significance Index: -0.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0483
    Cell Significance Index: -0.5800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0484
    Cell Significance Index: -0.6300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0533
    Cell Significance Index: -0.5700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0605
    Cell Significance Index: -0.8300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0660
    Cell Significance Index: -0.7300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0677
    Cell Significance Index: -0.7300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0741
    Cell Significance Index: -0.7500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0762
    Cell Significance Index: -0.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The OR4F4 gene is a single-copy gene located on chromosome 17q21.3. It encodes a G protein-coupled receptor (GPCR) that is activated by a specific ligand, which triggers a signaling cascade that ultimately leads to the perception of a particular odorant. The OR4F4 receptor is a member of the olfactory receptor subfamily F, which is characterized by a distinct amino acid sequence and a unique ligand binding site. **Pathways and Functions:** The OR4F4 gene is involved in several key pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell**: The OR4F4 receptor is activated by a specific odorant, which binds to the receptor and triggers a signaling cascade that ultimately leads to the perception of that odorant. 2. **Expression and translocation of olfactory receptors**: The OR4F4 gene is involved in the expression and translocation of olfactory receptors to the plasma membrane, where they can interact with ligands and trigger signaling cascades. 3. **G protein-coupled receptor activity**: The OR4F4 receptor is a GPCR that activates a signaling cascade that ultimately leads to the perception of a particular odorant. 4. **G protein-coupled receptor signaling pathway**: The OR4F4 receptor is part of a larger signaling pathway that involves multiple GPCRs, which work together to detect and respond to chemical stimuli. The OR4F4 gene plays a critical role in the olfactory system, which is essential for detecting and responding to chemical stimuli in the environment. This gene is also involved in other cellular processes, including the regulation of cell growth and differentiation. **Clinical Significance:** The OR4F4 gene has been implicated in various diseases and disorders, including: 1. **Olfactory disorders**: Mutations in the OR4F4 gene have been associated with olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurological disorders**: The OR4F4 gene has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, which are characterized by impaired olfactory function. 3. **Cancer**: The OR4F4 gene has been found to be overexpressed in certain types of cancer, including lung and breast cancer, which may contribute to tumor growth and metastasis. In conclusion, the OR4F4 gene is a critical component of the human olfactory system, and its dysregulation has been implicated in various diseases and disorders. Further research is needed to fully understand the role of this gene in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.