Details for: OR2W1

Gene ID: 26692

Symbol: OR2W1

Ensembl ID: ENSG00000204704

Description: olfactory receptor family 2 subfamily W member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 7.62
    Marker Score: 2413
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 4.58
    Marker Score: 2410
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.69
    Marker Score: 2413
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 2.47
    Marker Score: 1969
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.26
    Marker Score: 2394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 1.83
    Marker Score: 1668
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.75
    Marker Score: 2411
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.48
    Marker Score: 2397
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.44
    Marker Score: 9556
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.14
    Marker Score: 2357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.08
    Marker Score: 3222
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.04
    Marker Score: 6321
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.02
    Marker Score: 2404
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30330
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.89
    Marker Score: 2395
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4612
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.68
    Marker Score: 2410

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Other Information

**Key Characteristics:** OR2W1 is a G protein-coupled receptor that belongs to the olfactory receptor family, which is responsible for detecting odorant molecules in the air we breathe. This receptor is characterized by its unique structure, which consists of seven transmembrane domains and a large extracellular domain. The expression of OR2W1 is widespread, with significant levels detected in renal, intestinal, and epithelial cells, suggesting its involvement in multiple physiological processes. **Pathways and Functions:** OR2W1 is involved in the detection of chemical stimuli involved in sensory perception of smell, as well as the expression and translocation of olfactory receptors. The receptor's signaling pathway is mediated through G protein-coupled receptor activity, which activates a G protein and triggers a cascade of downstream signaling events. These events ultimately lead to the activation of various cellular responses, including changes in gene expression and cellular behavior. The functions of OR2W1 can be broadly categorized into two main groups: (1) sensory perception and (2) cellular regulation. In terms of sensory perception, OR2W1 is responsible for detecting odorant molecules, which bind to the receptor and trigger a signaling cascade. This cascade ultimately leads to the activation of olfactory neurons, which transmit the sensory information to the brain. In terms of cellular regulation, OR2W1 is involved in the regulation of gene expression and cellular behavior, including changes in cell proliferation, differentiation, and survival. **Clinical Significance:** OR2W1 has significant clinical implications, particularly in the context of olfactory disorders. Olfactory disorders, such as anosmia and hyposmia, are characterized by a reduced ability to detect odorant molecules, which can have significant impacts on quality of life. OR2W1 has been identified as a potential contributor to these disorders, suggesting that mutations or alterations in the expression of this receptor may contribute to the development of olfactory impairments. Furthermore, OR2W1 has been implicated in other diseases, including kidney disease and intestinal disorders. For example, studies have shown that OR2W1 is significantly expressed in renal and intestinal cells, suggesting its involvement in the regulation of kidney and intestinal function. Alterations in the expression or function of OR2W1 may contribute to the development of these diseases, highlighting the importance of this receptor in maintaining tissue homeostasis. In conclusion, OR2W1 is a novel olfactory receptor that plays a critical role in the detection of chemical stimuli and the sensory perception of smell. Its widespread expression in various tissues suggests its involvement in multiple physiological processes, and its clinical significance highlights its potential implications in human health and disease. Further research is needed to fully elucidate the functions and clinical significance of OR2W1, but this gene is undoubtedly an important contributor to our understanding of olfactory perception and its regulation.

Genular Protein ID: 3015158479

Symbol: OR2W1_HUMAN

Name: Olfactory receptor 2W1

UniProtKB Accession Codes:

Q9Y3N9 B0S7Y5 Q5JNZ1 Q6IEU0 Q96R17 Q9GZL0 Q9GZL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 25 Ensembl 8 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 320
  • Mass: 36101
  • Checksum: 7A8ECD33F443E1D0
  • Sequence:
    • MDQSNYSSLH GFILLGFSNH PKMEMILSGV VAIFYLITLV GNTAIILASL LDSQLHTPMY 
FFLRNLSFLD LCFTTSIIPQ MLVNLWGPDK TISYVGCIIQ LYVYMWLGSV ECLLLAVMSY 
DRFTAICKPL HYFVVMNPHL CLKMIIMIWS ISLANSVVLC TLTLNLPTCG NNILDHFLCE 
LPALVKIACV DTTTVEMSVF ALGIIIVLTP LILILISYGY IAKAVLRTKS KASQRKAMNT 
CGSHLTVVSM FYGTIIYMYL QPGNRASKDQ GKFLTLFYTV ITPSLNPLIY TLRNKDMKDA 
LKKLMRFHHK STKIKRNCKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.