Details for: OR2W1

Gene ID: 26692

Symbol: OR2W1

Ensembl ID: ENSG00000204704

Description: olfactory receptor family 2 subfamily W member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0313
    Cell Significance Index: 0.1900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0146
    Cell Significance Index: 0.1700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0030
    Cell Significance Index: 0.0300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.0028
    Cell Significance Index: 0.0200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0049
    Cell Significance Index: -0.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0053
    Cell Significance Index: -0.0800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0132
    Cell Significance Index: -0.2600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0489
    Cell Significance Index: -0.6400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0521
    Cell Significance Index: -0.5700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0548
    Cell Significance Index: -0.6400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0560
    Cell Significance Index: -0.6000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0728
    Cell Significance Index: -0.9800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0780
    Cell Significance Index: -0.8200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0784
    Cell Significance Index: -0.9600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0881
    Cell Significance Index: -1.0600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0936
    Cell Significance Index: -0.9900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1378
    Cell Significance Index: -1.2900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1462
    Cell Significance Index: -1.7300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2966
    Cell Significance Index: -1.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor:** OR2W1 is a member of the olfactory receptor family, which is responsible for detecting odorant molecules in the air and transmitting this information to the brain. 2. **GPCR Family:** OR2W1 belongs to the GPCR family, a large group of receptors that respond to a wide range of ligands, including hormones, neurotransmitters, and odorants. 3. **Expression:** OR2W1 is widely expressed in various tissues, including renal beta-intercalated cells, intestinal enteroendocrine cells, and epithelial cells. 4. **Signaling Pathway:** OR2W1 activates the G protein-coupled receptor signaling pathway, which involves the activation of G proteins and the subsequent modulation of downstream signaling pathways. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR2W1 detects chemical stimuli involved in sensory perception of smell, allowing individuals to perceive and distinguish different odors. 2. **Expression and Translocation:** OR2W1 is involved in the expression and translocation of olfactory receptors, ensuring that the correct receptors are expressed and transported to the plasma membrane. 3. **G Protein-Coupled Receptor Activity:** OR2W1 exhibits G protein-coupled receptor activity, which involves the activation of G proteins and the modulation of downstream signaling pathways. 4. **Sensory Perception:** OR2W1 plays a critical role in sensory perception, allowing individuals to perceive and distinguish different odors. **Clinical Significance:** 1. **Olfactory Disorders:** Mutations in the OR2W1 gene have been associated with olfactory disorders, such as anosmia and hyposmia, which can significantly impact an individual's quality of life. 2. **Kidney Function:** OR2W1 is also expressed in renal cells, suggesting its potential role in kidney function and disease. 3. **Intestinal Function:** OR2W1 is expressed in intestinal enteroendocrine cells, which are involved in the regulation of gut function and appetite. 4. **Cancer Research:** OR2W1 has been identified as a potential biomarker for cancer research, as its expression is altered in various types of cancer. In conclusion, the OR2W1 gene is a vital component of the human olfactory system, playing a critical role in sensory perception of smell. Its expression and function extend beyond olfaction, suggesting its involvement in multiple physiological processes. Further research is needed to fully elucidate the clinical significance of OR2W1 and its potential applications in disease diagnosis and treatment.

Genular Protein ID: 3015158479

Symbol: OR2W1_HUMAN

Name: Olfactory receptor 2W1

UniProtKB Accession Codes:

Q9Y3N9 B0S7Y5 Q5JNZ1 Q6IEU0 Q96R17 Q9GZL0 Q9GZL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 25 Ensembl 8 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 320
  • Mass: 36101
  • Checksum: 7A8ECD33F443E1D0
  • Sequence:
    • MDQSNYSSLH GFILLGFSNH PKMEMILSGV VAIFYLITLV GNTAIILASL LDSQLHTPMY 
FFLRNLSFLD LCFTTSIIPQ MLVNLWGPDK TISYVGCIIQ LYVYMWLGSV ECLLLAVMSY 
DRFTAICKPL HYFVVMNPHL CLKMIIMIWS ISLANSVVLC TLTLNLPTCG NNILDHFLCE 
LPALVKIACV DTTTVEMSVF ALGIIIVLTP LILILISYGY IAKAVLRTKS KASQRKAMNT 
CGSHLTVVSM FYGTIIYMYL QPGNRASKDQ GKFLTLFYTV ITPSLNPLIY TLRNKDMKDA 
LKKLMRFHHK STKIKRNCKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.