Details for: IGHJ2P

Gene ID: 28480

Symbol: IGHJ2P

Ensembl ID: ENSG00000237547

Description: immunoglobulin heavy joining 2P (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 8.3165
    Cell Significance Index: 162.6000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5002
    Cell Significance Index: 36.3400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0087
    Cell Significance Index: 0.1000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0060
    Cell Significance Index: -0.0700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0086
    Cell Significance Index: -0.0800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0144
    Cell Significance Index: -0.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0289
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0345
    Cell Significance Index: -0.3300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0402
    Cell Significance Index: -0.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.5225
    Cell Significance Index: -38.7900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -1.8537
    Cell Significance Index: -17.3400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -2.1504
    Cell Significance Index: -36.7600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -2.7171
    Cell Significance Index: -37.2600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -2.8646
    Cell Significance Index: -37.7000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -2.8705
    Cell Significance Index: -37.4700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -3.2437
    Cell Significance Index: -52.5400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -3.4817
    Cell Significance Index: -50.7500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -4.0393
    Cell Significance Index: -44.7400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -4.2060
    Cell Significance Index: -54.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene designation:** IGHJ2P is classified as a pseudogene due to its lack of functional coding potential. However, its expression in multiple cell types suggests that it may have evolved to play a regulatory or epigenetic role. 2. **Widespread expression:** IGHJ2P is significantly expressed in various cell types, including B cells, dendritic cells, plasma cells, erythrocytes, hematopoietic multipotent progenitor cells, megakaryocytes, hematopoietic stem cells, CD8-positive T cells, alpha-beta T cells, class-switched memory B cells, and double-negative thymocytes. 3. **Cell-type specificity:** The expression patterns of IGHJ2P vary across different cell types, suggesting that it may be involved in specific cellular processes or pathways. **Pathways and Functions:** 1. **Gene regulation:** IGHJ2P may act as a regulator of gene expression, influencing the transcriptional activity of nearby genes or influencing chromatin structure and epigenetic marks. 2. **Non-coding RNA (ncRNA) function:** IGHJ2P could be involved in the production of ncRNAs, which are known to play crucial roles in regulating gene expression and cellular processes. 3. **Epigenetic regulation:** IGHJ2P may participate in epigenetic modifications, such as DNA methylation or histone modification, which are essential for maintaining cellular identity and function. 4. **Cellular differentiation:** The expression of IGHJ2P may be involved in the regulation of cellular differentiation, particularly in the context of hematopoiesis and immune cell development. **Clinical Significance:** 1. **Immunological disorders:** The expression of IGHJ2P in various immune cells raises questions about its potential involvement in immunological disorders, such as autoimmune diseases or immune-related cancers. 2. **Cancer biomarkers:** IGHJ2P may serve as a biomarker for certain types of cancer, particularly those involving immune cells, such as multiple myeloma or lymphoma. 3. **Gene therapy:** A deeper understanding of IGHJ2P's function and regulation could provide insights into the development of novel gene therapy strategies for immune-related disorders. 4. **Basic research:** The study of IGHJ2P offers a unique opportunity to explore the complex relationships between pseudogenes, gene regulation, and cellular function, ultimately shedding light on the fundamental mechanisms governing the immune system. In conclusion, the IGHJ2P gene, despite being classified as a pseudogene, exhibits intriguing characteristics and expression patterns that warrant further investigation. As our understanding of this gene and its role in the immune system evolves, it is likely to reveal new avenues for research and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.