Details for: TRAJ58

Gene ID: 28697

Symbol: TRAJ58

Ensembl ID: ENSG00000211833

Description: T cell receptor alpha joining 58 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0025
    Cell Significance Index: -0.0500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0027
    Cell Significance Index: -0.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0136
    Cell Significance Index: -0.2500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0187
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0189
    Cell Significance Index: -0.1800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0195
    Cell Significance Index: -0.2000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0198
    Cell Significance Index: -0.2000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0215
    Cell Significance Index: -0.2500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0222
    Cell Significance Index: -0.2500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0224
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0229
    Cell Significance Index: -0.2000
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0305
    Cell Significance Index: -0.2500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0363
    Cell Significance Index: -0.3200
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0366
    Cell Significance Index: -0.2700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0418
    Cell Significance Index: -0.3700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0465
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0490
    Cell Significance Index: -0.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional gene**: TRAJ58 lacks the typical alpha chain joining domains, rendering it non-functional in the context of T cell receptor (TCR) assembly. 2. **Widespread expression**: TRAJ58 is significantly expressed in various immune cell types, including alpha-beta T cells, regulatory T cells, and natural killer cells. 3. **Cell type-specific expression**: TRAJ58 shows cell type-specific expression patterns, with varying levels of expression across different immune cell populations. 4. **Evolutionary conservation**: TRAJ58 is conserved across different species, suggesting its evolutionary significance in immune cell development and function. **Pathways and Functions:** 1. **T cell receptor (TCR) assembly**: TRAJ58 is involved in the assembly of the TCR complex, although its non-functional status prevents it from contributing to TCR assembly. 2. **Immune cell development**: TRAJ58 plays a role in the development of alpha-beta T cells, regulatory T cells, and natural killer cells, which are essential components of the adaptive immune response. 3. **Cell signaling and regulation**: TRAJ58 may influence cell signaling and regulation pathways, potentially affecting immune cell function and behavior. 4. **Gene regulation and expression**: TRAJ58 may interact with other genes and regulatory elements to modulate the expression of other genes involved in immune cell development and function. **Clinical Significance:** While TRAJ58 is a non-functional gene, its widespread expression and involvement in immune cell development and function make it an interesting candidate for further study. Potential applications of TRAJ58 research include: 1. **Immunodeficiency diseases**: Understanding the role of TRAJ58 in immune cell development and function may provide insights into the mechanisms underlying immunodeficiency diseases, such as severe combined immunodeficiency (SCID) and T cell leukemia. 2. **Cancer immunotherapy**: TRAJ58's involvement in T cell development and function may make it a target for cancer immunotherapy strategies, such as T cell activation and expansion. 3. **Gene therapy**: TRAJ58's expression in various immune cell types makes it a potential candidate for gene therapy applications, such as the correction of immune deficiencies or the enhancement of immune responses. In conclusion, TRAJ58 is a non-functional gene that plays a significant role in the development and function of various immune cells. While its non-functional status may limit its direct involvement in immune cell function, its widespread expression and involvement in immune cell development and function make it an interesting candidate for further study.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.