Details for: TRAJ19

Gene ID: 28736

Symbol: TRAJ19

Ensembl ID: ENSG00000211870

Description: T cell receptor alpha joining 19 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0723
    Cell Significance Index: 0.8100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.0036
    Cell Significance Index: 0.0700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0032
    Cell Significance Index: -0.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0065
    Cell Significance Index: -0.0800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0070
    Cell Significance Index: -0.1000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0105
    Cell Significance Index: -0.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0106
    Cell Significance Index: -0.1300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0121
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0128
    Cell Significance Index: -0.1200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0136
    Cell Significance Index: -0.1500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0137
    Cell Significance Index: -0.0700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0144
    Cell Significance Index: -0.1900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0170
    Cell Significance Index: -0.2100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0174
    Cell Significance Index: -0.2000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0222
    Cell Significance Index: -0.2700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0235
    Cell Significance Index: -0.3100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0242
    Cell Significance Index: -0.3000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0281
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0390
    Cell Significance Index: -0.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRAJ19 gene is a non-coding gene, meaning it does not encode a protein. Its expression is widespread, with significant levels found in mature NK T cells, CD8-positive T cells, alpha-beta T cells, stromal cells, and various neuronal populations, including retinal rod cells, Purkinje cells, and L2/3-6 intratelencephalic projecting glutamatergic neurons. Notably, TRAJ19 is also expressed in double-positive, alpha-beta thymocytes, which suggests a potential role in thymocyte development. **Pathways and Functions:** Despite its non-functional nature, TRAJ19 may play a role in regulating gene expression or influencing cellular signaling pathways. Its expression in various cell types suggests that TRAJ19 may be involved in cellular differentiation, development, or survival. For example, TRAJ19 may act as a regulatory element, influencing the expression of nearby genes or modulating signaling pathways that are crucial for thymocyte development or neuronal function. **Clinical Significance:** The TRAJ19 gene's widespread expression in various cell types raises questions about its clinical significance. While its non-functional nature may suggest a lack of direct involvement in disease pathogenesis, TRAJ19's expression in immune cells and neurons implies that it may play a role in regulating immune responses or modulating neuronal function. Further studies are needed to determine the functional significance of TRAJ19 and its potential involvement in disease. Furthermore, the TRAJ19 gene's expression in thymocytes suggests that it may be involved in thymocyte development or function. Thymocyte development is a critical process in the development of the immune system, and any disruptions in this process can lead to immunodeficiency or autoimmune diseases. Understanding the role of TRAJ19 in thymocyte development may provide insights into the molecular mechanisms underlying immune system dysfunction. In conclusion, the TRAJ19 gene's non-functional nature belies its widespread expression in various cell types. Further studies are needed to determine the functional significance of TRAJ19 and its potential involvement in disease. Its expression in thymocytes and neurons suggests that TRAJ19 may play a role in regulating cellular differentiation, development, or survival, and its clinical significance remains to be fully elucidated. **Recommendations:** 1. Further studies are needed to determine the functional significance of TRAJ19 and its potential involvement in disease. 2. Expression analysis of TRAJ19 in various cell types and tissues may provide insights into its role in cellular differentiation, development, or survival. 3. Functional studies, such as gene knockout or overexpression experiments, may be necessary to determine TRAJ19's functional significance. 4. Investigation of TRAJ19's expression in immune cells and neurons may provide insights into its potential involvement in immune system dysfunction or neurological disorders. **Limitations:** 1. The current understanding of TRAJ19's function is limited by its non-functional nature. 2. Further studies are needed to determine the functional significance of TRAJ19 and its potential involvement in disease. 3. The TRAJ19 gene's expression in various cell types may be influenced by environmental factors or other genes, which may complicate its functional analysis. **Future Directions:** 1. Expression analysis of TRAJ19 in various cell types and tissues may provide insights into its role in cellular differentiation, development, or survival. 2. Functional studies, such as gene knockout or overexpression experiments, may be necessary to determine TRAJ19's functional significance. 3. Investigation of TRAJ19's expression in immune cells and neurons may provide insights into its potential involvement in immune system dysfunction or neurological disorders. 4. Comparative genomics and transcriptomics studies may provide insights into TRAJ19's evolutionary significance and functional role.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.