Details for: KRT41P

Gene ID: 8686

Symbol: KRT41P

Ensembl ID: ENSG00000225438

Description: keratin 41, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0198
    Cell Significance Index: 1.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0104
    Cell Significance Index: -0.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0162
    Cell Significance Index: -0.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0173
    Cell Significance Index: -1.8000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0299
    Cell Significance Index: -0.3800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0600
    Cell Significance Index: -0.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0605
    Cell Significance Index: -1.3300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0615
    Cell Significance Index: -0.6700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0739
    Cell Significance Index: -0.6700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0815
    Cell Significance Index: -0.9700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1012
    Cell Significance Index: -0.6000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1018
    Cell Significance Index: -0.6400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1186
    Cell Significance Index: -1.3600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1188
    Cell Significance Index: -1.2100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1309
    Cell Significance Index: -1.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1393
    Cell Significance Index: -1.3200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1440
    Cell Significance Index: -2.0500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1594
    Cell Significance Index: -1.5000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1662
    Cell Significance Index: -2.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1706
    Cell Significance Index: -2.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1785
    Cell Significance Index: -2.4400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2565
    Cell Significance Index: -1.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT41P is a pseudogene, meaning that it lacks a functional gene within its coding region. However, it is still transcribed and processed, suggesting that it may have evolved to serve a specific purpose. The Ensembl ID ENSG00000225438 assigns KRT41P to the human genome, indicating that it is a legitimate gene sequence. Notably, KRT41P is expressed in a wide range of cell types, including those from the nervous system, epithelial tissues, and the central nervous system. This widespread expression underscores the potential importance of KRT41P in maintaining tissue homeostasis and cellular function. **Pathways and Functions:** While the exact mechanisms by which KRT41P operates remain unclear, several pathways and functions have been proposed based on its expression patterns and functional associations: 1. **Cell signaling and communication:** KRT41P may play a role in modulating cell signaling pathways, particularly those involved in neuronal communication and synaptic plasticity. Its expression in glutamatergic neurons and oligodendrocytes suggests that it may be involved in the regulation of excitatory neurotransmission and myelination. 2. **Epithelial maintenance and differentiation:** KRT41P is expressed in bladder urothelial cells and pigmented epithelial cells, suggesting that it may contribute to the maintenance of epithelial tissues and the regulation of cellular differentiation. 3. **Neuroprotection and degeneration:** The expression of KRT41P in neurons and oligodendrocytes raises the possibility that it may play a role in neuroprotection and degeneration. Its pseudogenous status may enable it to modulate cellular responses to stress and injury. **Clinical Significance:** The clinical significance of KRT41P remains a topic of ongoing research. However, its expression in various human tissues and cell types suggests that it may be involved in a range of physiological and pathological processes. Potential applications of KRT41P include: 1. **Neurological disorders:** KRT41P's expression in neurons and oligodendrocytes may make it a useful biomarker for neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Cancer research:** The expression of KRT41P in bladder urothelial cells and pigmented epithelial cells raises the possibility that it may be involved in the development and progression of cancer. 3. **Gene therapy and regenerative medicine:** KRT41P's pseudogenous status may enable it to be used as a gene therapy vector, delivering therapeutic genes to specific cell types and tissues. In conclusion, the KRT41P gene is a complex and multifaceted pseudogene that has been found to be significantly expressed in various human tissues. While its exact mechanisms of action remain unclear, its expression patterns and functional associations suggest that it may play a range of roles in regulating cellular processes and maintaining tissue homeostasis. Further research is needed to fully elucidate the clinical significance of KRT41P and its potential applications in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.