Details for: RNA5SP507

Gene ID: 100873558

Symbol: RNA5SP507

Ensembl ID: ENSG00000200473

Description: RNA, 5S ribosomal pseudogene 507

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.5299
    Cell Significance Index: 5.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0027
    Cell Significance Index: 0.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0039
    Cell Significance Index: -0.1000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0102
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0122
    Cell Significance Index: -0.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0129
    Cell Significance Index: -0.1400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0139
    Cell Significance Index: -0.1800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0215
    Cell Significance Index: -0.2300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0224
    Cell Significance Index: -0.2800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0234
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0293
    Cell Significance Index: -0.3500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0342
    Cell Significance Index: -0.4000
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0414
    Cell Significance Index: -0.4500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0425
    Cell Significance Index: -0.4700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0501
    Cell Significance Index: -0.4600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0506
    Cell Significance Index: -0.5000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0506
    Cell Significance Index: -0.6200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0526
    Cell Significance Index: -0.5700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0604
    Cell Significance Index: -0.5700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0684
    Cell Significance Index: -0.6500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0795
    Cell Significance Index: -0.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** The RNA5SP507 gene is located on chromosome 1q21.1, a region that has been associated with various genetic disorders. 2. **Type:** RNA5SP507 is a 5S ribosomal pseudogene, which is a type of non-coding RNA that is typically found in the nucleolus and plays a role in ribosome biogenesis. 3. **Expression:** RNA5SP507 is significantly expressed in various cell types within the intestinal tissue, including intestinal enteroendocrine cells, brush cells, and goblet cells. 4. **Cell types:** RNA5SP507 has been found to be expressed in a variety of cell types, including intestinal epithelial cells, absorptive cells, neoplastic cells, and abnormal cells. **Pathways and Functions:** 1. **Ribosome biogenesis:** RNA5SP507 is involved in ribosome biogenesis, specifically in the process of rRNA processing and modification. 2. **Cellular homeostasis:** The expression of RNA5SP507 in intestinal cells may play a role in maintaining cellular homeostasis and regulating cellular processes. 3. **Cell signaling:** RNA5SP507 may be involved in cell signaling pathways, including the regulation of cell proliferation and differentiation. 4. **Stem cell maintenance:** RNA5SP507 has been found to be expressed in intestinal crypt stem cells, suggesting that it may play a role in maintaining stem cell function and regulating intestinal homeostasis. **Clinical Significance:** 1. **Intestinal disorders:** The expression of RNA5SP507 in intestinal disorders, such as inflammatory bowel disease (IBD) and colorectal cancer, may provide insights into the molecular mechanisms underlying these diseases. 2. **Cancer diagnosis:** RNA5SP507 may serve as a potential biomarker for the diagnosis of colorectal cancer and other intestinal cancers. 3. **Stem cell transplantation:** The expression of RNA5SP507 in intestinal crypt stem cells may provide insights into the role of this gene in maintaining stem cell function and regulating intestinal homeostasis. 4. **Gene therapy:** RNA5SP507 may be a potential target for gene therapy in the treatment of intestinal disorders and cancers. In conclusion, the RNA5SP507 gene is a pseudogene with widespread expression in intestinal tissue, suggesting that it may play a role in maintaining cellular homeostasis and regulating cellular processes. Further research is needed to fully elucidate the functional significance of this pseudogene and its potential applications in the treatment of intestinal disorders and cancers.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.