MYCBP2 AS1 | ENSG00000236051 | NCBI 100874212

Details for: MYCBP2 AS1

Gene ID: 100874212

Gene Type: ncRNA (Non-coding RNA) - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: MYCBP2 AS1

Ensembl ID: ENSG00000236051

Description: MYCBP2 antisense RNA 1

Cell Significance Landscape

Display Count:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

retinal cone cell CL0000573

CSI 3.88

rCSI 6.25%

PRS 93.98
adipocyte CL0000136

CSI 3.69

rCSI 4.74%

PRS 94.34
glycinergic amacrine cell CL4030028

CSI 3.4

rCSI 8.87%

PRS 93.95
amacrine cell CL0000561

CSI 3.18

rCSI 9.21%

PRS 93.84
inhibitory interneuron CL0000498

CSI 2.96

rCSI 6.82%

PRS 93.8
alveolar macrophage CL0000583

CSI 2.91

rCSI 4.79%

PRS 98.1
rod bipolar cell CL0000751

CSI 2.67

rCSI 4.81%

PRS 95.29
Mueller cell CL0000636

CSI 2.43

rCSI 5.56%

PRS 95.08
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 1.95

rCSI 4.75%

PRS 91.79
glutamatergic neuron CL0000679

CSI 1.87

rCSI 3.85%

PRS 91.23
cardiac muscle cell CL0000746

CSI 1.86

rCSI 2.68%

PRS 93.74
GABAergic amacrine cell CL4030027

CSI 1.64

rCSI 5.63%

PRS 91.04
OFFx cell CL4033036

CSI 1.59

rCSI 7.5%

PRS 91.23
diffuse bipolar 6 cell CL4033032

CSI 1.53

rCSI 8.05%

PRS 91.82
retinal ganglion cell CL0000740

CSI 1.46

rCSI 3.23%

PRS 93.1
H1 horizontal cell CL0004217

CSI 1.4

rCSI 5.54%

PRS 93.89
ON midget ganglion cell CL4033046

CSI 1.34

rCSI 27.22%

PRS 93.11
ON parasol ganglion cell CL4033052

CSI 1.32

rCSI 18.79%

PRS 93.34
indirect pathway medium spiny neuron CL4023029

CSI 1.26

rCSI 30.33%

PRS 90.84
OFF midget ganglion cell CL4033047

CSI 1.17

rCSI 23.79%

PRS 93.22
direct pathway medium spiny neuron CL4023026

CSI 0.94

rCSI 22.48%

PRS 91.08
invaginating midget bipolar cell CL4033034

CSI 0.91

rCSI 5.36%

PRS 92.49
H2 horizontal cell CL0004218

CSI 0.83

rCSI 4.12%

PRS 94.43
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.82

rCSI 2.96%

PRS 91.98
flat midget bipolar cell CL4033033

CSI 0.71

rCSI 5.06%

PRS 91.99

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

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Node Color (Target Cell CSI, relative to current network):
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- High
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- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description

## Summary [MYCBP2 AS1](/details-gene/100874212) is a non-coding antisense RNA located on chromosome 13q22.3. Expression data indicates that this gene has a highly specific and significant role within the retina, showing prominent expression in a diverse array of retinal cell types, including [retinal cone cells](/details-cell/CL0000573) and various interneurons. Its high significance is also noted in [adipocytes](/details-cell/CL0000136) and certain neuronal populations outside the eye. As an antisense transcript, its primary function is likely regulatory, potentially controlling the expression or function of its sense-strand counterpart, [MYCBP2](/details-gene/29116). ## Cellular Roles and Expression Landscape The expression profile of [MYCBP2 AS1](/details-gene/100874212) points to a specialized function, predominantly within the neural retina. **Overall**, it demonstrates the highest significance in [retinal cone cells](/details-cell/CL0000573) (CSI: 3.88), suggesting a key role in photoreceptor biology. Its high expression extends across the retinal architecture, including various interneurons such as [glycinergic amacrine cells](/details-cell/CL4030028) (CSI: 3.40), [amacrine cells](/details-cell/CL0000561) (CSI: 3.18), and [rod bipolar cells](/details-cell/CL0000751) (CSI: 2.67), as well as supportive [Mueller cells](/details-cell/CL0000636) (CSI: 2.43). This broad yet specific expression pattern within the retina suggests its involvement in complex processes such as visual signal processing, synaptic organization, or cellular maintenance. Beyond the retina, [MYCBP2 AS1](/details-gene/100874212) shows notable significance in several other distinct cell types. Its high score in [adipocytes](/details-cell/CL0000136) (CSI: 3.69) indicates a potential, uncharacterized role in lipid metabolism or adipogenesis. Furthermore, its expression in central nervous system cells like [inhibitory interneurons](/details-cell/CL0000498) (CSI: 2.96) and [glutamatergic neurons](/details-cell/CL0000679) (CSI: 1.87), as well as in seemingly unrelated cell types like [alveolar macrophages](/details-cell/CL0000583) (CSI: 2.91) and [cardiac muscle cells](/details-cell/CL0000746) (CSI: 1.86), highlights a potentially pleiotropic function that may be highly context-dependent. The collective data portrays [MYCBP2 AS1](/details-gene/100874212) as a highly specific marker for retinal cell subtypes, with additional significant roles in select non-ocular tissues. ## Pathways and Molecular Function Specific functional annotation data, such as Gene Ontology (GO) and Reactome pathways, were not available in the provided dataset. However, as an antisense non-coding RNA, [MYCBP2 AS1](/details-gene/100874212) is predicted to function as a post-transcriptional regulator. It may act by binding to the mRNA of its sense counterpart, [MYCBP2](/details-gene/29116), a gene encoding an E3 ubiquitin ligase. Such interaction could influence the stability, translation, or splicing of the [MYCBP2](/details-gene/29116) transcript, thereby modulating protein levels and downstream ubiquitin-mediated processes within the cell types where it is highly expressed. ## Research Directions The highly specific expression pattern of [MYCBP2 AS1](/details-gene/100874212) in the retina and other specialized cells raises several intriguing questions about its biological role and therapeutic potential. **Proposed Hypotheses:** 1. **[MYCBP2 AS1](/details-gene/100874212) is a critical regulator of retinal cell fate or function.** Given its exceptionally high expression across multiple retinal layers, it is hypothesized that [MYCBP2 AS1](/details-gene/100874212) plays a crucial role in the development, differentiation, or homeostatic maintenance of retinal neurons and glia, possibly by fine-tuning the ubiquitin ligase activity of its sense partner, [MYCBP2](/details-gene/29116). 2. **[MYCBP2 AS1](/details-gene/100874212) modulates adipocyte metabolism or differentiation.** The strong and specific signal in [adipocytes](/details-cell/CL0000136) suggests that this lncRNA could be involved in regulating key aspects of fat cell biology, such as adipogenesis, lipolysis, or insulin sensitivity, representing a novel regulatory axis in metabolic health. **Suggested Experimental Approach:** To test the hypothesis that [MYCBP2 AS1](/details-gene/100874212) is essential for retinal function, a loss-of-function study could be performed using human induced pluripotent stem cell (iPSC)-derived retinal organoids. Targeted knockdown of [MYCBP2 AS1](/details-gene/100874212) using antisense oligonucleotides (ASOs) could be followed by single-cell RNA sequencing (scRNA-seq) to identify changes in cell type proportions and gene expression networks. Concurrently, functional assays, such as multi-electrode array (MEA) recordings, could assess whether the loss of this ncRNA impairs the electrophysiological activity and network connectivity of the developing retina. **Therapeutic Potential:** As a non-coding RNA with a highly restricted expression pattern, particularly in the eye, [MYCBP2 AS1](/details-gene/100874212) presents a promising therapeutic target. Its specificity for retinal cells could allow for targeted therapies with minimal off-target effects in other tissues. If dysregulation of [MYCBP2 AS1](/details-gene/100874212) is implicated in retinal degenerative diseases, RNA-based therapeutics like ASOs delivered via intravitreal injection could be developed. The strategy would likely involve inhibition, aiming to restore normal levels of the transcript if it is pathologically overexpressed.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.