Details for: OSCP1

Gene ID: 127700

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: OSCP1

Ensembl ID: ENSG00000116885

Description: organic solute carrier partner 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lung ciliated cell CL1000271
    CSI 10.87
    rCSI 12.57%
    PRS 96.85
  • ciliated epithelial cell CL0000067
    CSI 10.52
    rCSI 9.25%
    PRS 95.68
  • multi-ciliated epithelial cell CL0005012
    CSI 9.56
    rCSI 9.54%
    PRS 96.65
  • ciliated cell CL0000064
    CSI 5.81
    rCSI 9.42%
    PRS 95.93
  • deuterosomal cell CL4033044
    CSI 5.2
    rCSI 17.57%
    PRS 95.54
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 5.1
    rCSI 11.63%
    PRS 95.59
  • retinal rod cell CL0000604
    CSI 4.58
    rCSI 8.07%
    PRS 96.81
  • pancreatic D cell CL0000173
    CSI 4.03
    rCSI 3.96%
    PRS 98.57
  • ependymal cell CL0000065
    CSI 4.02
    rCSI 8.15%
    PRS 92.19
  • glioblast CL0000030
    CSI 3.65
    rCSI 5.82%
    PRS 96.23
  • type B pancreatic cell CL0000169
    CSI 3.27
    rCSI 7.23%
    PRS 98.25
  • squamous epithelial cell CL0000076
    CSI 3.24
    rCSI 7.69%
    PRS 96.14
  • choroid plexus epithelial cell CL0000706
    CSI 3.06
    rCSI 5.02%
    PRS 96.94
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.03
    rCSI 3.78%
    PRS 94.89
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.55
    rCSI 3.04%
    PRS 95.51
  • retinal cone cell CL0000573
    CSI 2.12
    rCSI 3.41%
    PRS 95.82
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.97
    rCSI 3.31%
    PRS 95.79
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.17
    rCSI 2.85%
    PRS 94.32
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.73
    rCSI 2.64%
    PRS 94.7

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [OSCP1](/details-gene/127700), or Organic Solute Carrier Partner 1, is a protein-coding gene located on chromosome 1p34.3. Functionally, it is annotated as a transmembrane transporter involved in the plasma membrane, particularly the basal membrane ([GO:0009925](https://www.ebi.ac.uk/QuickGO/term/GO:0009925)). Its primary role is associated with [transmembrane transporter activity](/details-go/GO:0022857), including the detoxification of xenobiotics through transmembrane export ([GO:1990961](https://www.ebi.ac.uk/QuickGO/term/GO:1990961)). **Overall**, expression data reveals that [OSCP1](/details-gene/127700) is a highly significant marker for multiple types of ciliated cells, including [lung ciliated cell](/details-cell/CL1000271) and [ciliated epithelial cell](/details-cell/CL0000067), suggesting a specialized function in tissues requiring motile cilia for clearance and sensory functions. ## Cellular Roles and Expression Landscape The expression profile of [OSCP1](/details-gene/127700) strongly indicates a crucial role in ciliated epithelial lineages. It exhibits its highest Cell Significance Index (CSI) scores in [lung ciliated cell](/details-cell/CL1000271) (CSI: 10.87), [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 10.52), and [multi-ciliated epithelial cell](/details-cell/CL0005012) (CSI: 9.56). This pattern is further supported by significant expression in related cell types such as [deuterosomal cell](/details-cell/CL4033044), a precursor to multi-ciliated cells, and [ciliated columnar cell of tracheobronchial tree](/details-cell/CL0002145). Beyond the respiratory system, its significance in other ciliated or specialized cell types like [retinal rod cell](/details-cell/CL0000604), [ependymal cell](/details-cell/CL0000065), and [choroid plexus epithelial cell](/details-cell/CL0000706) suggests a conserved function in cellular transport across diverse tissues. The high CSI values in these specific populations indicate that [OSCP1](/details-gene/127700) likely serves as a highly active and important workhorse molecule, critical for the specialized functions of these cells. Its expression has also been noted in endocrine cells, such as [pancreatic D cell](/details-cell/CL0000173), suggesting a potential role in hormone-secreting tissues. ## Pathways and Molecular Function The functional annotations for [OSCP1](/details-gene/127700) align well with its cellular expression pattern. Its involvement in [Xenobiotic detoxification by transmembrane export across the plasma membrane](/details-go/GO:1990961) is particularly relevant for its high expression in the tracheobronchial tree, where epithelial cells form a primary barrier against inhaled toxins and pathogens. As a molecule with [Transmembrane transporter activity](/details-go/GO:0022857), it is localized to the [plasma membrane](/details-go/GO:0005886) and [cytoplasm](/details-go/GO:0005737). Functional characterization studies have confirmed its identity as a novel organic solute carrier protein ([Link](https://doi.org/10.1074/jbc.m504246200)), responsible for transporting substrates across the cell membrane. This transport function is fundamental to maintaining cellular homeostasis and protecting cells from harmful external compounds. ## Research Directions The specific expression of [OSCP1](/details-gene/127700) in ciliated cells, coupled with its role in xenobiotic transport, opens several avenues for future research. Additionally, prior studies have noted its downregulation in nasopharyngeal carcinoma cell lines ([Link](https://doi.org/10.1007/s00432-003-0451-9)), suggesting a potential role in cancer biology. **Proposed Testable Hypotheses:** 1. The high expression of [OSCP1](/details-gene/127700) in respiratory ciliated cells is a key defense mechanism against airborne toxins, and reduced [OSCP1](/details-gene/127700) function contributes to epithelial damage in chronic respiratory diseases such as COPD or cystic fibrosis. 2. Based on previous findings ([Link](https://doi.org/10.1007/s00432-003-0451-9)), downregulation of [OSCP1](/details-gene/127700) in nasopharyngeal and other epithelial cancers may serve as a tumor-promoting event, potentially by altering cellular metabolism or sensitivity to endogenous toxic byproducts, suggesting it may function as a tumor suppressor. 3. In [retinal rod cell](/details-cell/CL0000604) and pancreatic endocrine cells, [OSCP1](/details-gene/127700) may transport specific endogenous metabolites or signaling molecules crucial for photoreception or hormone regulation, respectively. **Key Experimental Approach:** To test the first hypothesis, the role of [OSCP1](/details-gene/127700) in respiratory epithelial defense could be investigated using an air-liquid interface (ALI) culture of primary human bronchial epithelial cells. [OSCP1](/details-gene/127700) expression could be knocked down using siRNA, followed by exposure to cigarette smoke extract. The impact on cell viability, ciliary beat frequency, mucus production, and the inflammatory response (e.g., IL-8 secretion) could then be quantified to determine if [OSCP1](/details-gene/127700) is essential for protecting the airway epithelium from damage. **Therapeutic Potential:** Given its function as a transporter and its reported downregulation in cancer ([Link](https://doi.org/10.1007/s00432-003-0451-9)), [OSCP1](/details-gene/127700) is an unlikely candidate for therapeutic inhibition. Instead, it may represent a potential tumor suppressor. If its loss is confirmed to contribute to malignancy, strategies aimed at restoring its expression or function, perhaps through small-molecule activators, could be explored as a novel therapeutic approach. Furthermore, its expression level could serve as a valuable prognostic biomarker in epithelial cancers.

Genular Protein ID: 1807871060

Symbol: OSCP1_HUMAN

Name: Protein OSCP1

UniProtKB Accession Codes:

Q8WVF1 A6NHM5 A6NHS9 A6NIN9 Q4AEJ0 Q8N7G2 Q8TDF1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 3 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12819961

Title: Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE-1 nasopharyngeal carcinoma cell line.

PubMed ID: 12819961

DOI: 10.1007/s00432-003-0451-9

PubMed ID: 16006562

Title: Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1.

PubMed ID: 16006562

DOI: 10.1074/jbc.m504246200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 389
  • Mass: 44586
  • Checksum: 8EA5C1EF2D9973F4
  • Sequence:
    • MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKDEW TEVDRKRVLN DIISTMFNRK 
FMEELFKPQE LYSKKALRTV YERLAHASIM KLNQASMDKL YDLMTMAFKY QVLLCPRPKD 
VLLVTFNHLD TIKGFIRDSP TILQQVDETL RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH 
IRVSMFLKDK VQNNNGRFVL PVSGPVPWGT EVPGLIRMFN NKGEEVKRIE FKHGGNYVPA 
PKEGSFELYG DRVLKLGTNM YSVNQPVETH VSGSSKNLAS WTQESIAPNP LAKEELNFLA 
RLMGGMEIKK PSGPEPGFRL NLFTTDEEEE QAALTRPEEL SYEVINIQAT QDQQRSEELA 
RIMGEFEITE QPRLSTSKGD DLLAMMDEL