Details for: TTTY20

Gene ID: 252951

Symbol: TTTY20

Ensembl ID: ENSG00000232808

Description: testis expressed transcript, Y-linked 20

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.7118
    Cell Significance Index: 7.8000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0778
    Cell Significance Index: 1.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0040
    Cell Significance Index: -0.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0067
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0106
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0117
    Cell Significance Index: -0.2300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0118
    Cell Significance Index: -0.1100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0122
    Cell Significance Index: -0.1600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0138
    Cell Significance Index: -0.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0154
    Cell Significance Index: -0.3400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0163
    Cell Significance Index: -0.1700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0170
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0175
    Cell Significance Index: -0.1900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0182
    Cell Significance Index: -0.1400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0198
    Cell Significance Index: -0.1700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0199
    Cell Significance Index: -0.2400
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0213
    Cell Significance Index: -0.2300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0213
    Cell Significance Index: -0.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0225
    Cell Significance Index: -0.2600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0286
    Cell Significance Index: -0.2700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0450
    Cell Significance Index: -0.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1418
    Cell Significance Index: -1.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TTY20 is a small, non-coding RNA gene that is primarily expressed in the testis, with a relatively low expression level in other tissues. Its Y-linked location suggests a possible role in sex-specific gene regulation or male fertility. Interestingly, TTTY20 is also expressed in various intestinal cells, including enteroendocrine cells, goblet cells, and intestinal epithelial cells. This widespread expression across different tissues is a hallmark of TTTY20, and its cellular localization is characterized by its presence in the nucleus and cytoplasm of these cells. **Pathways and Functions:** Despite its non-coding nature, TTTY20 has been implicated in various cellular processes, including cell proliferation, differentiation, and survival. Research has shown that TTTY20 is involved in the regulation of cell cycle progression and apoptosis in intestinal cells. Additionally, TTTY20 has been shown to interact with other genes and proteins involved in the Wnt/β-catenin signaling pathway, which is critical for maintaining intestinal homeostasis. The exact mechanisms by which TTTY20 influences these pathways remain unclear, but its presence in intestinal cells suggests a potential role in maintaining the balance of the intestinal epithelium. **Clinical Significance:** The clinical significance of TTTY20 is an area of ongoing research. Given its expression in various intestinal cells, TTTY20 may play a role in the development and maintenance of intestinal disorders, such as inflammatory bowel disease (IBD) or colorectal cancer. Studies have shown that TTTY20 is overexpressed in certain types of cancer, including colorectal cancer, suggesting a potential role as a tumor suppressor. Furthermore, TTTY20's interaction with the Wnt/β-catenin signaling pathway makes it a potential target for therapy in IBD and other intestinal disorders. In conclusion, the TTTY20 gene is a fascinating example of the complex interplay between gene expression, cellular localization, and disease pathology. Further research is needed to fully elucidate the functional significance of TTTY20 in intestinal homeostasis and its potential role in various diseases. As an expert immunologist, it is essential to continue exploring the intricacies of this enigmatic gene and its far-reaching implications for our understanding of human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.