Details for: SNORA68

Gene ID: 26780

Symbol: SNORA68

Ensembl ID: ENSG00000207166

Description: small nucleolar RNA, H/ACA box 68

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0868
    Cell Significance Index: 0.6800
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0127
    Cell Significance Index: 0.1300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0028
    Cell Significance Index: 0.0500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0113
    Cell Significance Index: -0.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0119
    Cell Significance Index: -0.6200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0193
    Cell Significance Index: -0.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0300
    Cell Significance Index: -0.3500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0306
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0337
    Cell Significance Index: -0.4100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0378
    Cell Significance Index: -0.4500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0386
    Cell Significance Index: -0.4500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0431
    Cell Significance Index: -0.2500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0516
    Cell Significance Index: -0.6100
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0589
    Cell Significance Index: -0.6000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0595
    Cell Significance Index: -0.6100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0626
    Cell Significance Index: -0.6200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0642
    Cell Significance Index: -0.5300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0671
    Cell Significance Index: -0.5900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0722
    Cell Significance Index: -0.8100
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: -0.0943
    Cell Significance Index: -0.6300
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.1828
    Cell Significance Index: -0.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene location and expression pattern:** SNORA68 is situated on chromosome 2q11.2 and exhibits a broad expression profile, with significant expression in pericytes, cardiac endothelial cells, and smooth muscle myoblasts. 2. **H/ACA box snoRNA family:** SNORA68 belongs to the H/ACA box snoRNA family, which is characterized by a specific nucleotide sequence and a unique structure. 3. **RNA processing regulation:** SNORA68 regulates rRNA processing, a critical step in ribosome biogenesis, by interacting with the nucleolus and modulating the expression of rRNA genes. 4. **Post-transcriptional regulation:** SNORA68 exerts its regulatory effects post-transcriptionally, influencing the stability and translation of target mRNAs. **Pathways and Functions:** 1. **Nucleolus:** SNORA68 interacts with the nucleolus, a critical organelle involved in rRNA processing, to regulate the expression of rRNA genes. 2. **RNA processing pathways:** SNORA68 modulates the activity of RNA processing pathways, including the 5' untranslated region (5' UTR) binding protein (UAP) and the nuclear RNA export receptor (NOR) pathways. 3. **Ribosome biogenesis:** SNORA68 regulates ribosome biogenesis by controlling the expression of rRNA genes, which are essential for protein synthesis. 4. **Cellular differentiation:** SNORA68 influences cellular differentiation by modulating the expression of genes involved in cell type-specific processes. **Clinical Significance:** 1. **Cancer:** Aberrant expression of SNORA68 has been linked to various types of cancer, including colorectal, breast, and lung cancer, suggesting its potential as a diagnostic biomarker or therapeutic target. 2. **Neurodegenerative disorders:** SNORA68 may play a role in neurodegenerative diseases, such as Alzheimer's and Parkinson's, due to its involvement in RNA processing and its expression in neuronal cells. 3. **Cardiac disease:** SNORA68 is expressed in cardiac cells and may contribute to cardiac development and function, highlighting its potential as a therapeutic target for cardiovascular disease. 4. **Immune system regulation:** SNORA68 influences the expression of genes involved in immune system regulation, suggesting its potential role in immune-mediated diseases. In conclusion, SNORA68 is a critical regulator of RNA processing, with significant implications for our understanding of cellular differentiation, tissue development, and disease. Further research is necessary to fully elucidate the functions and clinical significance of this enigmatic gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.