Details for: TRBV26

Gene ID: 28561

Symbol: TRBV26

Ensembl ID: ENSG00000249912

Description: T cell receptor beta variable 26 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0346
    Cell Significance Index: 0.3300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0199
    Cell Significance Index: 0.2400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0027
    Cell Significance Index: 0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0017
    Cell Significance Index: -0.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0047
    Cell Significance Index: -0.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0048
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0148
    Cell Significance Index: -0.1400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0167
    Cell Significance Index: -0.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0179
    Cell Significance Index: -0.3800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0185
    Cell Significance Index: -0.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0194
    Cell Significance Index: -0.3800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0196
    Cell Significance Index: -0.2100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0203
    Cell Significance Index: -0.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0217
    Cell Significance Index: -0.2600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0228
    Cell Significance Index: -0.2500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0234
    Cell Significance Index: -0.2900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0240
    Cell Significance Index: -0.3200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0256
    Cell Significance Index: -0.2200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0323
    Cell Significance Index: -0.3500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0332
    Cell Significance Index: -0.3600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0396
    Cell Significance Index: -0.3800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0442
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** TRBV26 is classified as a pseudogene, which suggests that it has undergone degradation or inactivation, rendering it non-functional. 2. **Expression profile:** TRBV26 is significantly expressed in specific cell types within the CNS, including GABAergic cortical interneurons and glutamatergic neurons. 3. **Ensembl ID:** The TRBV26 gene is designated as ENSG00000249912, indicating its unique genomic location. **Pathways and Functions:** 1. **Immune system involvement:** Despite being a pseudogene, TRBV26 may still contribute to the immune system, potentially influencing T-cell receptor (TCR) signaling or immune response regulation. 2. **CNS-specific functions:** TRBV26's expression in CNS cells suggests that it may play a role in neuronal development, synaptic plasticity, or neurotransmission. 3. **Gene regulation:** TRBV26 may interact with other genes or regulatory elements to modulate gene expression in the CNS. **Clinical Significance:** 1. **Neurological disorders:** The expression of TRBV26 in specific CNS cells raises the possibility that it may be involved in the pathogenesis of neurological disorders, such as autism spectrum disorder (ASD), schizophrenia, or epilepsy. 2. **Neurodevelopmental disorders:** TRBV26's role in neuronal development and synaptic plasticity may be critical in understanding neurodevelopmental disorders, such as ASD or intellectual disability. 3. **Immunological implications:** The presence of TRBV26 in immune cells within the CNS may have implications for our understanding of immune regulation in the brain and the development of novel therapeutic strategies. In conclusion, the TRBV26 gene, despite its pseudogene status, has garnered attention for its unique expression profile in the CNS. Further research is necessary to elucidate the functional significance of TRBV26 and its potential role in neurological and immunological disorders. As an expert immunologist, it is essential to continue exploring the characteristics, pathways, and functions of TRBV26 to uncover its clinical significance and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.