Details for: TRAJ57

Gene ID: 28698

Symbol: TRAJ57

Ensembl ID: ENSG00000211834

Description: T cell receptor alpha joining 57

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0206
    Cell Significance Index: 0.2300
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0042
    Cell Significance Index: 0.0500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0013
    Cell Significance Index: 0.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0047
    Cell Significance Index: -0.0400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0088
    Cell Significance Index: -0.0900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0119
    Cell Significance Index: -0.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0121
    Cell Significance Index: -0.1200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0143
    Cell Significance Index: -0.1900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0143
    Cell Significance Index: -0.1100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0159
    Cell Significance Index: -0.1700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0162
    Cell Significance Index: -0.1900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0165
    Cell Significance Index: -0.1900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0168
    Cell Significance Index: -0.1700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0169
    Cell Significance Index: -0.1700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0188
    Cell Significance Index: -0.1900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0199
    Cell Significance Index: -0.2000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0199
    Cell Significance Index: -0.1500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0205
    Cell Significance Index: -0.1800
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0210
    Cell Significance Index: -0.1900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0220
    Cell Significance Index: -0.1900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0231
    Cell Significance Index: -0.1300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0234
    Cell Significance Index: -0.2000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0625
    Cell Significance Index: -0.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRAJ57 is highly expressed in T cells, particularly in alpha-beta T cells, which are the most common type of T cells. 2. **Genomic Location:** The TRAJ57 gene is located on chromosome 11, and its Ensembl ID is ENSG00000211834. 3. **Protein Function:** TRAJ57 is involved in the joining of the TCR alpha chain to the TCR beta chain, forming a functional TCR complex. 4. **Cellular Distribution:** TRAJ57 is expressed in various T cell subsets, including innate lymphoid cells, T cells, and thymocytes. **Pathways and Functions:** 1. **T Cell Receptor (TCR) Complex Formation:** TRAJ57 is essential for the formation of the TCR complex, which recognizes and binds to specific antigens. 2. **T Cell Activation:** The TCR complex plays a critical role in T cell activation, which involves the recognition of antigens by the TCR and the subsequent activation of T cells. 3. **Immune Response:** TRAJ57 is involved in the regulation of the immune response, particularly in the context of cell-mediated immunity. 4. **Thymocyte Development:** TRAJ57 is expressed in thymocytes, which are precursor cells to mature T cells, and plays a role in their development and maturation. **Clinical Significance:** 1. **Immunodeficiency Diseases:** Mutations in the TRAJ57 gene have been associated with immunodeficiency diseases, such as severe combined immunodeficiency (SCID). 2. **Autoimmune Diseases:** TRAJ57 has been implicated in the pathogenesis of autoimmune diseases, such as type 1 diabetes and multiple sclerosis. 3. **Cancer Immunotherapy:** TRAJ57 is a potential target for cancer immunotherapy, as it plays a critical role in the recognition and activation of T cells against tumor cells. 4. **Vaccine Development:** Understanding the function of TRAJ57 in T cell development and activation can inform the development of novel vaccine strategies. In conclusion, TRAJ57 is a crucial gene in T cell development and function, and its dysregulation can lead to immunodeficiency diseases and autoimmune disorders. Further research is necessary to fully understand the role of TRAJ57 in the immune system and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.