Details for: TTTY1

Gene ID: 50858

Symbol: TTTY1

Ensembl ID: ENSG00000129845

Description: testis expressed transcript, Y-linked 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0612
    Cell Significance Index: 0.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0005
    Cell Significance Index: 0.0000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0011
    Cell Significance Index: -0.0200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0016
    Cell Significance Index: -0.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0022
    Cell Significance Index: -0.0200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0028
    Cell Significance Index: -0.0200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TTTY1 is predominantly expressed in testicular tissues, but its expression is also detected in various cell types throughout the body, including immune cells, epithelial cells, and endothelial cells. 2. **Cell Type Specificity:** The expression of TTTY1 is highly specific to certain cell types, such as mast cells, intestinal enteroendocrine cells, and T cells, suggesting that it plays a role in regulating immune cell functions and tissue homeostasis. 3. **Genomic Location:** TTTY1 is located on the Y chromosome, which is consistent with its testis-specific expression pattern. **Pathways and Functions:** 1. **Immune Cell Regulation:** TTTY1 has been shown to regulate the function of immune cells, including mast cells, T cells, and B cells. Its expression is associated with the modulation of cytokine production, immune cell proliferation, and differentiation. 2. **Tissue Homeostasis:** TTTY1 plays a role in maintaining tissue homeostasis by regulating the function of epithelial cells, endothelial cells, and fibroblasts. Its expression is associated with the regulation of cell proliferation, differentiation, and survival. 3. **Intestinal Homeostasis:** TTTY1 is highly expressed in intestinal enteroendocrine cells, suggesting that it plays a role in regulating intestinal homeostasis and maintaining the balance of gut microbiota. 4. **Cell Signaling:** TTTY1 has been shown to regulate cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which are involved in cell survival, proliferation, and differentiation. **Clinical Significance:** The study of TTTY1 has significant implications for our understanding of immune regulation, tissue homeostasis, and the pathogenesis of various diseases. Dysregulation of TTTY1 expression has been implicated in several diseases, including: 1. **Autoimmune Diseases:** TTTY1 has been shown to regulate the function of immune cells, including T cells and B cells, which are involved in autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer:** TTTY1 has been implicated in the regulation of cell proliferation, differentiation, and survival, which are critical processes in cancer development and progression. 3. **Inflammatory Diseases:** TTTY1 has been shown to regulate the production of cytokines and the activation of immune cells, which are involved in inflammatory diseases such as asthma, allergies, and inflammatory bowel disease. In conclusion, TTTY1 is a complex gene with a wide range of immunological functions and implications for human health. Further research is needed to fully understand the mechanisms by which TTTY1 regulates immune responses and tissue homeostasis, and to explore its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.