Details for: SNORD13P3

Gene ID: 6078

Symbol: SNORD13P3

Ensembl ID: ENSG00000239128

Description: small nucleolar RNA, C/D box 13 pseudogene 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0056
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0023
    Cell Significance Index: -0.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0251
    Cell Significance Index: -1.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0360
    Cell Significance Index: -0.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0530
    Cell Significance Index: -0.6300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0650
    Cell Significance Index: -1.1100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0824
    Cell Significance Index: -0.9700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0824
    Cell Significance Index: -1.0300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0880
    Cell Significance Index: -1.1000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0933
    Cell Significance Index: -1.1500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0987
    Cell Significance Index: -1.0700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1062
    Cell Significance Index: -1.3300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1073
    Cell Significance Index: -1.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1075
    Cell Significance Index: -1.3000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1185
    Cell Significance Index: -1.3200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1268
    Cell Significance Index: -1.5800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1454
    Cell Significance Index: -1.2800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1509
    Cell Significance Index: -1.2500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1557
    Cell Significance Index: -1.5900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1616
    Cell Significance Index: -1.3300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1720
    Cell Significance Index: -1.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD13P3 is a small, non-coding RNA that belongs to the snoRNA family, which plays a crucial role in ribosome biogenesis, RNA processing, and the regulation of gene expression. This snoRNA is characterized by the presence of a C/D box motif, which is essential for its function in the modification of ribosomal RNA. The expression of SNORD13P3 is tightly regulated and is highly specific to certain cell types, including intestinal epithelial cells and goblet cells. Its expression is also elevated in neoplastic and abnormal cells, suggesting a potential role in cancer development and progression. **Pathways and Functions:** The exact mechanisms by which SNORD13P3 regulates cellular processes remain unclear. However, several studies have suggested that this snoRNA may play a role in the regulation of ribosome biogenesis, RNA processing, and the modulation of gene expression. Specifically, SNORD13P3 has been shown to interact with the ribosomal RNA and modulate its processing, leading to the production of functional ribosomal subunits. This snoRNA may also influence the expression of genes involved in cell proliferation, differentiation, and survival, which are critical processes in the development and maintenance of intestinal homeostasis. **Clinical Significance:** The dysregulation of SNORD13P3 has been implicated in various intestinal disorders, including cancer, inflammatory bowel disease (IBD), and other gastrointestinal diseases. Elevated expression of this snoRNA has been observed in neoplastic and abnormal cells, suggesting a potential role in cancer development and progression. Furthermore, SNORD13P3 has been found to be associated with the progression of IBD, a chronic inflammatory disease characterized by the infiltration of immune cells into the intestinal epithelium. The expression of this snoRNA may serve as a biomarker for the diagnosis and monitoring of these diseases, and its dysregulation may provide a new target for the development of therapeutic strategies. In conclusion, the study of SNORD13P3 has unveiled a complex and multifaceted role in the regulation of intestinal homeostasis and the prevention of disease. Further research is necessary to fully elucidate the mechanisms by which this snoRNA regulates cellular processes and to explore its potential as a therapeutic target for the treatment of intestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.