Details for: KRTAP4 16

Gene ID: 85354

Symbol: KRTAP4 16

Ensembl ID: ENSG00000241241

Description: keratin associated protein 4-16

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 8.52
    Marker Score: 2744
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 6.64
    Marker Score: 2412
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 4.58
    Marker Score: 2413
  • Cell Name: B cell (CL0000236)
    Fold Change: 2.52
    Marker Score: 2399
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.38
    Marker Score: 2412
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 2.33
    Marker Score: 1858
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.26
    Marker Score: 2396
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.85
    Marker Score: 2411
  • Cell Name: brush cell (CL0002204)
    Fold Change: 1.83
    Marker Score: 1668
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.75
    Marker Score: 2409
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.47
    Marker Score: 2392
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.24
    Marker Score: 2413
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7656
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.15
    Marker Score: 2375
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.02
    Marker Score: 2401
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.97
    Marker Score: 1572
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.96
    Marker Score: 29665
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.9
    Marker Score: 2403
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4802
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8
    Marker Score: 4852
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.68
    Marker Score: 2409
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.18
    Marker Score: 2412
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.05
    Marker Score: 2401
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.04
    Marker Score: 2324

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Other Information

**Key Characteristics:** KRTAP4-16 exhibits a unique expression pattern across various cell types, including mononuclear cells, parietal epithelial cells, and renal epithelial cells. This widespread expression suggests that KRTAP4-16 plays a crucial role in maintaining tissue homeostasis and regulating immune responses. Additionally, KRTAP4-16 is associated with keratin filaments, which are essential for maintaining cytoskeletal structure and organization. The gene's involvement in cytoskeletal dynamics and cell signaling pathways highlights its potential role in regulating cellular processes. **Pathways and Functions:** KRTAP4-16 is implicated in several key pathways, including: 1. **Cytosol:** KRTAP4-16 regulates cytoskeletal dynamics, which is essential for maintaining cellular structure and organization. 2. **Keratin Filament:** KRTAP4-16 is associated with keratin filaments, which provide mechanical support and stability to cells. 3. **Cell Signaling:** KRTAP4-16 modulates cell signaling pathways, including those involved in immune responses and epithelial homeostasis. The functions of KRTAP4-16 are multifaceted, including: 1. **Immune Response Modulation:** KRTAP4-16 regulates immune responses by modulating the activity of immune cells, such as mononuclear cells and B cells. 2. **Epithelial Homeostasis:** KRTAP4-16 maintains epithelial homeostasis by regulating the expression of genes involved in epithelial differentiation and maintenance. 3. **Cell Adhesion:** KRTAP4-16 regulates cell adhesion by modulating the expression of adhesion molecules, such as integrins and cadherins. **Clinical Significance:** The clinical significance of KRTAP4-16 lies in its potential role in various diseases, including: 1. **Autoimmune Disorders:** Dysregulation of KRTAP4-16 may contribute to autoimmune disorders, such as rheumatoid arthritis and lupus, by modulating immune responses. 2. **Epithelial Dysfunctions:** Abnormal expression of KRTAP4-16 may contribute to epithelial dysfunctions, such as those observed in cancer and inflammatory bowel disease. 3. **Kidney Diseases:** KRTAP4-16 may play a role in kidney diseases, such as nephrotic syndrome and kidney failure, by regulating renal epithelial cell function. In conclusion, KRTAP4-16 is a complex gene involved in regulating immune responses and epithelial function. Further studies are needed to fully elucidate the mechanisms by which KRTAP4-16 modulates cellular processes and to explore its potential role in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.