RAD51AP1 | ENSG00000111247 | NCBI 10635

Details for: RAD51AP1

Gene ID: 10635

Symbol: RAD51AP1

Ensembl ID: ENSG00000111247

Description: RAD51 associated protein 1

Associated with

Defective hdr through homologous recombination repair (hrr) due to palb2 loss of brca1 binding function
(R-HSA-9704331)
Defective hdr through homologous recombination repair (hrr) due to palb2 loss of brca2/rad51/rad51c binding function
(R-HSA-9704646)
Defective homologous recombination repair (hrr) due to brca1 loss of function
(R-HSA-9701192)
Defective homologous recombination repair (hrr) due to brca2 loss of function
(R-HSA-9701190)
Defective homologous recombination repair (hrr) due to palb2 loss of function
(R-HSA-9701193)
Disease
(R-HSA-1643685)
Diseases of dna double-strand break repair
(R-HSA-9675136)
Diseases of dna repair
(R-HSA-9675135)
Dna double-strand break repair
(R-HSA-5693532)
Hdr through homologous recombination (hrr)
(R-HSA-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homologous dna pairing and strand exchange
(R-HSA-5693579)
Homology directed repair
(R-HSA-5693538)
Impaired brca2 binding to palb2
(R-HSA-9709603)
Resolution of d-loop structures
(R-HSA-5693537)
Resolution of d-loop structures through holliday junction intermediates
(R-HSA-5693568)
Resolution of d-loop structures through synthesis-dependent strand annealing (sdsa)
(R-HSA-5693554)
Cellular response to ionizing radiation
(GO:0071479)
Chromatin
(GO:0000785)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
D-loop dna binding
(GO:0062037)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Dna secondary structure binding
(GO:0000217)
Double-strand break repair via homologous recombination
(GO:0000724)
Double-stranded dna binding
(GO:0003690)
Interstrand cross-link repair
(GO:0036297)
Meiotic cell cycle
(GO:0051321)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of double-strand break repair via homologous recombination
(GO:1905168)
Positive regulation of reciprocal meiotic recombination
(GO:0010845)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of double-strand break repair via homologous recombination
(GO:0010569)
Rna binding
(GO:0003723)
Single-stranded dna binding
(GO:0003697)

Other Information

Proteins

R51A1_HUMAN

Genular Protein ID: 2134074733

Symbol: R51A1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96B01 A8K7D3 O43403 Q7Z779

Database IDs:

Citations:

PubMed ID: 9396801

Title: A novel nucleic acid-binding protein that interacts with human rad51 recombinase.

PubMed ID: 9396801

DOI: 10.1093/nar/25.24.4946

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16990250

Title: RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51.

PubMed ID: 16990250

DOI: 10.1093/nar/gkl665

PubMed ID: 17996710

Title: RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination.

PubMed ID: 17996710

DOI: 10.1016/j.molcel.2007.08.025

PubMed ID: 17996711

Title: Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement.

PubMed ID: 17996711

DOI: 10.1016/j.molcel.2007.08.027

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20871616

Title: Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

PubMed ID: 20871616

DOI: 10.1038/nsmb.1916

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21903585

Title: RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif.

PubMed ID: 21903585

DOI: 10.1074/jbc.m111.290015

PubMed ID: 21307306

Title: Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).

PubMed ID: 21307306

DOI: 10.1073/pnas.1016454108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22375013

Title: Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair.

PubMed ID: 22375013

DOI: 10.1074/jbc.c112.352161

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23754376

Title: FIGNL1-containing protein complex is required for efficient homologous recombination repair.

PubMed ID: 23754376

DOI: 10.1073/pnas.1220662110

PubMed ID: 25288561

Title: RAD51AP1-deficiency in vertebrate cells impairs DNA replication.

PubMed ID: 25288561

DOI: 10.1016/j.dnarep.2014.09.007

PubMed ID: 26323318

Title: NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.

PubMed ID: 26323318

DOI: 10.1093/nar/gkv859

PubMed ID: 27463890

Title: The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.

PubMed ID: 27463890

DOI: 10.1080/15384101.2016.1209613

PubMed ID: 27239033

Title: Promotion of RAD51-mediated homologous DNA pairing by the RAD51AP1-UAF1 complex.

PubMed ID: 27239033

DOI: 10.1016/j.celrep.2016.05.007

PubMed ID: 31253762

Title: DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response.

PubMed ID: 31253762

DOI: 10.1038/s41467-019-10408-5

PubMed ID: 31400850

Title: RAD51AP1 is an essential mediator of alternative lengthening of telomeres.

PubMed ID: 31400850

DOI: 10.1016/j.molcel.2019.06.043

PubMed ID: 31585101

Title: RAD51AP1 is an essential mediator of alternative lengthening of telomeres.

PubMed ID: 31585101

DOI: 10.1016/j.molcel.2019.08.009

PubMed ID: 32350107

Title: The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair.

PubMed ID: 32350107

DOI: 10.1074/jbc.ra120.013714

Sequence Information:

Length: 352
Mass: 38457
Checksum: E582EE4BC459DD92
Sequence:

MVRPVRHKKP VNYSQFDHSD SDDDFVSATV PLNKKSRTAP KELKQDKPKP NLNNLRKEEI 
PVQEKTPKKR LPEGTFSIPA SAVPCTKMAL DDKLYQRDLE VALALSVKEL PTVTTNVQNS 
QDKSIEKHGS SKIETMNKSP HISNCSVASD YLDLDKITVE DDVGGVQGKR KAASKAAAQQ 
RKILLEGSDG DSANDTEPDF APGEDSEDDS DFCESEDNDE DFSMRKSKVK EIKKKEVKVK 
SPVEKKEKKS KSKCNALVTS VDSAPAAVKS ESQSLPKKVS LSSDTTRKPL EIRSPSAESK 
KPKWVPPAAS GGSRSSSSPL VVVSVKSPNQ SLRLGLSRLA RVKPLHPNAT ST

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RAD51AP1

Associated with

Other Information

A novel nucleic acid-binding protein that interacts with human rad51 recombinase. PubMed ID: 9396801

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. PubMed ID: 16990250

RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination. PubMed ID: 17996710

Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement. PubMed ID: 17996711

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. PubMed ID: 20871616

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif. PubMed ID: 21903585

Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1). PubMed ID: 21307306

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair. PubMed ID: 22375013

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

FIGNL1-containing protein complex is required for efficient homologous recombination repair. PubMed ID: 23754376

RAD51AP1-deficiency in vertebrate cells impairs DNA replication. PubMed ID: 25288561

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. PubMed ID: 26323318

The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair. PubMed ID: 27463890

Promotion of RAD51-mediated homologous DNA pairing by the RAD51AP1-UAF1 complex. PubMed ID: 27239033

DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response. PubMed ID: 31253762

RAD51AP1 is an essential mediator of alternative lengthening of telomeres. PubMed ID: 31400850

RAD51AP1 is an essential mediator of alternative lengthening of telomeres. PubMed ID: 31585101

The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair. PubMed ID: 32350107