Details for: SNORD54

Gene ID: 26795

Symbol: SNORD54

Ensembl ID: ENSG00000238650

Description: small nucleolar RNA, C/D box 54

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0203
    Cell Significance Index: 0.2400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0165
    Cell Significance Index: 0.2000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.0087
    Cell Significance Index: 0.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0014
    Cell Significance Index: -0.3900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0077
    Cell Significance Index: -0.4000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0135
    Cell Significance Index: -0.1300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0163
    Cell Significance Index: -0.2200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0182
    Cell Significance Index: -0.1800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0198
    Cell Significance Index: -0.2500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0252
    Cell Significance Index: -0.2700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0288
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0306
    Cell Significance Index: -0.4000
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0324
    Cell Significance Index: -0.3700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0331
    Cell Significance Index: -0.3900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0332
    Cell Significance Index: -0.3900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0337
    Cell Significance Index: -0.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0339
    Cell Significance Index: -0.4000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0341
    Cell Significance Index: -0.3900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0364
    Cell Significance Index: -0.4000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0415
    Cell Significance Index: -0.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0446
    Cell Significance Index: -0.5900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0539
    Cell Significance Index: -0.6800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0570
    Cell Significance Index: -0.6100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0621
    Cell Significance Index: -0.5100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0690
    Cell Significance Index: -0.5300
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0808
    Cell Significance Index: -0.3900
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.1631
    Cell Significance Index: -0.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD54 is a C/D box snoRNA, which is a subclass of snoRNAs that primarily regulate RNA processing events. snoRNAs are known to bind to specific RNA sequences, influencing the splicing, modification, and stability of RNA molecules. SNORD54, in particular, has been shown to be highly expressed in cells involved in immune responses, such as pericytes and innate lymphoid cells. This gene's expression is also observed in cardiac tissue, suggesting its potential role in cardiovascular health. **Pathways and Functions:** The primary function of SNORD54 is to regulate RNA processing events, including splicing and modification. snoRNAs like SNORD54 interact with specific RNAs, influencing their processing and stability. In the context of immune regulation, SNORD54 is thought to play a role in the maturation and activation of innate lymphoid cells, which are crucial for the initiation of immune responses. Additionally, SNORD54 may influence the expression of genes involved in cellular differentiation and survival, highlighting its potential role in maintaining cellular homeostasis. **Clinical Significance:** The significance of SNORD54 in clinical settings is an area of active research. Dysregulation of SNORD54 has been implicated in various diseases, including cardiovascular disorders and immune-mediated conditions. For instance, alterations in SNORD54 expression have been observed in patients with heart failure and myocardial infarction. Furthermore, studies have suggested that SNORD54 may play a role in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Understanding the mechanisms by which SNORD54 regulates RNA processing and immune responses may provide valuable insights into the development of novel therapeutic strategies for these diseases. In conclusion, SNORD54 is a critical gene involved in RNA processing and immune regulation. Its expression in various cell types, including pericytes and innate lymphoid cells, highlights its potential role in maintaining cellular homeostasis and regulating immune responses. Further research is necessary to elucidate the mechanisms by which SNORD54 functions and to explore its clinical significance in the context of various diseases. **Recommendations for Future Research:** 1. Investigate the specific RNA processing events regulated by SNORD54 in different cell types. 2. Explore the functional consequences of SNORD54 dysregulation in the context of immune-mediated diseases. 3. Develop novel therapeutic strategies targeting SNORD54 for the treatment of cardiovascular and autoimmune disorders. 4. Conduct comprehensive expression analysis of SNORD54 in various tissues and disease states to identify potential biomarkers for diagnosis and prognosis. By advancing our understanding of SNORD54's role in RNA processing and immune regulation, we may uncover new avenues for therapeutic intervention and improve our ability to diagnose and treat a range of diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.