Details for: SNORD36A

Gene ID: 26815

Symbol: SNORD36A

Ensembl ID: ENSG00000199744

Description: small nucleolar RNA, C/D box 36A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0507
    Cell Significance Index: 0.5700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0047
    Cell Significance Index: -1.3500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0066
    Cell Significance Index: -0.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0209
    Cell Significance Index: -0.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0266
    Cell Significance Index: -0.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0271
    Cell Significance Index: -1.4100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0412
    Cell Significance Index: -0.5200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0445
    Cell Significance Index: -0.6000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0471
    Cell Significance Index: -0.5900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0483
    Cell Significance Index: -0.6000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0514
    Cell Significance Index: -0.6500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0674
    Cell Significance Index: -0.5600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0771
    Cell Significance Index: -0.5900
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0894
    Cell Significance Index: -0.6200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0980
    Cell Significance Index: -1.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1027
    Cell Significance Index: -1.3400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1054
    Cell Significance Index: -1.1300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1110
    Cell Significance Index: -1.2700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1182
    Cell Significance Index: -1.3900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1186
    Cell Significance Index: -1.1700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1195
    Cell Significance Index: -1.4200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1205
    Cell Significance Index: -1.4200
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.2695
    Cell Significance Index: -1.3000
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.4057
    Cell Significance Index: -0.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Small nucleolar RNA (snoRNA) structure:** SNORD36A belongs to the snoRNA family, which is characterized by its small size (typically 30-40 nucleotides) and specific secondary structure features, including C/D box motifs. 2. **Cell-type specificity:** SNORD36A is significantly expressed in a wide range of cell types, including type A and D enteroendocrine cells, pancreatic cells, oligodendrocyte precursor cells, macrophages, and monocytes. 3. **RNA processing and regulation:** SNORD36A is involved in regulating RNA processing, including splicing and modification, which is crucial for maintaining genome stability and cell function. **Pathways and Functions:** 1. **Nucleolus formation and function:** SNORD36A is implicated in the formation and regulation of the nucleolus, a critical organelle involved in ribosome biogenesis and RNA processing. 2. **RNA processing and modification:** SNORD36A influences RNA processing, including splicing, capping, and polyadenylation, which are essential for the maturation and stability of RNA molecules. 3. **Cell differentiation and proliferation:** SNORD36A may play a role in regulating cell differentiation and proliferation, particularly in enteroendocrine cells and pancreatic cells. 4. **Immune cell function:** SNORD36A is expressed in immune cells, suggesting its involvement in regulating immune responses and modulating inflammation. **Clinical Significance:** 1. **Cancer association:** SNORD36A has been linked to various cancers, including pancreatic cancer, suggesting its potential role in tumorigenesis and cancer progression. 2. **Neurological disorders:** SNORD36A's expression in oligodendrocyte precursor cells and its involvement in nucleolus formation may contribute to neurological disorders, such as multiple sclerosis. 3. **Immune-related diseases:** SNORD36A's expression in immune cells may influence the development and progression of immune-related diseases, such as autoimmune disorders and inflammatory conditions. 4. **Therapeutic applications:** Further research is needed to identify potential therapeutic targets for SNORD36A, which could lead to the development of novel treatments for related diseases. In conclusion, SNORD36A is a complex and enigmatic RNA molecule with far-reaching implications in cellular regulation and disease. Further investigation into its functions, pathways, and clinical significance is crucial to unraveling its potential as a therapeutic target and to elucidating its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.