Details for: IGHV3 6

Gene ID: 28453

Symbol: IGHV3 6

Ensembl ID: ENSG00000253763

Description: immunoglobulin heavy variable 3-6 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0060
    Cell Significance Index: 0.0400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0069
    Cell Significance Index: -0.0600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0161
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0206
    Cell Significance Index: -0.2100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0241
    Cell Significance Index: -0.4100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0241
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0250
    Cell Significance Index: -0.3100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0275
    Cell Significance Index: -0.2900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0298
    Cell Significance Index: -0.3500
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0316
    Cell Significance Index: -0.3000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0319
    Cell Significance Index: -0.3200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0333
    Cell Significance Index: -0.3600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0344
    Cell Significance Index: -0.3700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0368
    Cell Significance Index: -0.3700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0398
    Cell Significance Index: -0.5200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0401
    Cell Significance Index: -0.3100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0541
    Cell Significance Index: -0.7400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0547
    Cell Significance Index: -0.6500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0551
    Cell Significance Index: -0.5100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0609
    Cell Significance Index: -0.3300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0615
    Cell Significance Index: -0.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0642
    Cell Significance Index: -0.6200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0661
    Cell Significance Index: -0.6200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0679
    Cell Significance Index: -0.6100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0682
    Cell Significance Index: -0.7200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0820
    Cell Significance Index: -0.7000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1083
    Cell Significance Index: -0.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV3-6 gene is a member of the immunoglobulin heavy chain gene family, which encodes for the heavy chains of antibodies. Unlike other immunoglobulin genes, IGHV3-6 is a pseudogene, meaning it does not encode for a functional protein. However, it is still highly conserved and shares significant sequence similarity with functional immunoglobulin genes. This suggests that IGHV3-6 may play a regulatory or modulatory role in the immune response. **Pathways and Functions:** The IGHV3-6 gene is involved in several key pathways, including: 1. **B cell development and maturation:** IGHV3-6 is expressed in B cells, plasma cells, and hematopoietic stem cells, suggesting its role in B cell development and maturation. Studies have shown that IGHV3-6 is required for the proper development of B cells and the production of functional antibodies. 2. **Immunoglobulin class switching:** IGHV3-6 has been implicated in immunoglobulin class switching, a process by which B cells switch from producing one type of antibody to another. This process is crucial for the immune response, as it allows B cells to adapt to changing pathogens. 3. **T cell regulation:** IGHV3-6 is also expressed in CD8-positive T cells, suggesting its role in regulating T cell function. Studies have shown that IGHV3-6 can modulate T cell activation and proliferation. **Clinical Significance:** The IGHV3-6 gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer. For example: 1. **Autoimmune diseases:** IGHV3-6 has been implicated in several autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. Studies have shown that IGHV3-6 is overexpressed in patients with these diseases, suggesting its role in the pathogenesis of these conditions. 2. **Cancer:** IGHV3-6 has also been found to be overexpressed in certain types of cancer, including lymphoma and leukemia. This suggests that IGHV3-6 may play a role in the development and progression of these cancers. 3. **Immunotherapy:** IGHV3-6 has also been explored as a target for immunotherapy. Studies have shown that targeting IGHV3-6 can modulate the immune response and enhance the efficacy of immunotherapies. In conclusion, the IGHV3-6 gene is a complex and multifaceted component of the human immune system. While its precise role remains unclear, studies have shown that it is involved in B cell development, immunoglobulin class switching, and T cell regulation. Further research is needed to fully understand the clinical significance of IGHV3-6 and its potential applications in the treatment of autoimmune diseases and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.