Details for: IGLV3 32

Gene ID: 28787

Symbol: IGLV3 32

Ensembl ID: ENSG00000211657

Description: immunoglobulin lambda variable 3-32 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0704
    Cell Significance Index: -0.7200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0708
    Cell Significance Index: -0.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0725
    Cell Significance Index: -1.3400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0827
    Cell Significance Index: -0.8400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1171
    Cell Significance Index: -1.0700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1216
    Cell Significance Index: -0.8100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1332
    Cell Significance Index: -1.2400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1374
    Cell Significance Index: -2.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1386
    Cell Significance Index: -3.9900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1533
    Cell Significance Index: -2.0000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1736
    Cell Significance Index: -2.0500
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.1748
    Cell Significance Index: -1.7100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1767
    Cell Significance Index: -1.6400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1853
    Cell Significance Index: -2.1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1878
    Cell Significance Index: -2.0800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2041
    Cell Significance Index: -2.2800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2057
    Cell Significance Index: -2.3700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2085
    Cell Significance Index: -1.9500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2162
    Cell Significance Index: -2.0500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2226
    Cell Significance Index: -2.3900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2292
    Cell Significance Index: -2.4100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2393
    Cell Significance Index: -2.0400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2749
    Cell Significance Index: -2.9300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2913
    Cell Significance Index: -1.5900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3381
    Cell Significance Index: -2.6300
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.3464
    Cell Significance Index: -2.8200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3775
    Cell Significance Index: -4.5900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3879
    Cell Significance Index: -5.1500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.3925
    Cell Significance Index: -3.5100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.4387
    Cell Significance Index: -3.0400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.4783
    Cell Significance Index: -2.5600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.5965
    Cell Significance Index: -3.8100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.6533
    Cell Significance Index: -7.0700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.8549
    Cell Significance Index: -10.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV3-32 is a non-functional immunoglobulin lambda variable segment, meaning it does not encode for a functional antibody. However, it is significantly expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells. Its expression is not limited to the immune system, as it has been detected in other tissues such as the brain, heart, and lung. IGLV3-32 is also notable for its high degree of polymorphism, with multiple alleles and variants being present in the human genome. **Pathways and Functions:** IGLV3-32 has been implicated in several cellular pathways, including the adaptive immune response, extracellular space, and immune response. Its non-functional nature belies its potential role in modulating immune responses, with IGLV3-32 being involved in regulating T-cell activation, B-cell differentiation, and antibody production. Additionally, IGLV3-32 has been shown to interact with other immune-related genes, influencing the expression of cytokines and chemokines involved in inflammation and tissue repair. Furthermore, IGLV3-32 has been implicated in the regulation of cell proliferation and differentiation, particularly in the context of cancer. Its expression has been detected in neoplastic cells, suggesting a potential role in tumorigenesis. IGLV3-32 may also contribute to the maintenance of tissue homeostasis, with its expression being upregulated in response to tissue damage or inflammation. **Clinical Significance:** IGLV3-32 has been associated with several immune-related disorders, including autoimmune diseases, allergies, and cancer. Its expression has been detected in patients with rheumatoid arthritis, lupus, and multiple sclerosis, suggesting a potential role in the pathogenesis of these diseases. Additionally, IGLV3-32 has been implicated in the development of cancer, with its expression being upregulated in various types of tumors. Furthermore, IGLV3-32 has been identified as a potential biomarker for immune-related disorders, with its expression levels being correlated with disease severity and prognosis. Its non-functional nature belies its potential as a therapeutic target, with IGLV3-32 being considered as a potential candidate for immunomodulatory therapies. In conclusion, IGLV3-32 is a non-functional immunoglobulin lambda variable segment that has been implicated in various cellular processes, including immune response, cell proliferation, and tissue homeostasis. Its clinical significance is evident, with its expression being associated with immune-related disorders and cancer. Further research is needed to fully elucidate the role of IGLV3-32 in human disease, but its potential as a therapeutic target and biomarker is undeniable.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.