Details for: KRT18P1

Gene ID: 3879

Symbol: KRT18P1

Ensembl ID: ENSG00000228666

Description: keratin 18 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1259
    Cell Significance Index: 1.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0379
    Cell Significance Index: 1.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0042
    Cell Significance Index: -0.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0144
    Cell Significance Index: -0.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0145
    Cell Significance Index: -0.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0286
    Cell Significance Index: -0.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0303
    Cell Significance Index: -1.4100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0365
    Cell Significance Index: -0.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0376
    Cell Significance Index: -1.0200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0421
    Cell Significance Index: -0.5000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0531
    Cell Significance Index: -0.5900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0676
    Cell Significance Index: -0.7300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0732
    Cell Significance Index: -0.6900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0764
    Cell Significance Index: -0.8700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0853
    Cell Significance Index: -0.9300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0935
    Cell Significance Index: -1.2000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0940
    Cell Significance Index: -1.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0990
    Cell Significance Index: -1.0800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1129
    Cell Significance Index: -0.6700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1146
    Cell Significance Index: -1.2400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1591
    Cell Significance Index: -1.6900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1645
    Cell Significance Index: -1.3600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1927
    Cell Significance Index: -2.0300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1956
    Cell Significance Index: -2.1500
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.2377
    Cell Significance Index: -1.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT18P1 shares a high degree of sequence similarity with its parent gene, keratin 18 (KRT18), which is a type II intermediate filament protein essential for maintaining cell integrity and structure. However, unlike KRT18, KRT18P1 lacks the ability to produce a functional protein, making it a pseudogene. The expression of KRT18P1 in bladder urothelial cells and neurons suggests that it may have a specialized function in these tissues, possibly related to cell differentiation, maintenance, or response to injury. **Pathways and Functions:** While the exact mechanisms of KRT18P1 are unclear, several pathways may be involved in its function: 1. **Cell signaling:** KRT18P1 may play a role in regulating cell signaling pathways, particularly those involved in bladder urothelial cell function and response to injury. 2. **Epithelial-to-mesenchymal transition (EMT):** KRT18P1 may influence EMT, a process by which epithelial cells acquire mesenchymal characteristics, contributing to tissue repair and regeneration. 3. **Neuroprotection:** KRT18P1's expression in neurons suggests that it may have neuroprotective properties, potentially shielding these cells from damage or stress. **Clinical Significance:** The discovery of KRT18P1's expression in bladder urothelial cells and neurons raises several clinical implications: 1. **Bladder cancer:** KRT18P1's expression in bladder urothelial cells may serve as a biomarker for bladder cancer diagnosis or progression. 2. **Neurological disorders:** KRT18P1's presence in neurons may be associated with neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Tissue engineering:** Understanding the function of KRT18P1 may provide insights into the development of novel tissue engineering strategies for bladder repair and regeneration. In conclusion, KRT18P1 is a pseudogene with significant expression in bladder urothelial cells and neurons, suggesting a specialized function in these tissues. Further research is needed to elucidate the mechanisms of KRT18P1 and its clinical significance, but its discovery highlights the complex and multifaceted nature of gene function in human cells.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.