Details for: MIR150

Gene ID: 406942

Symbol: MIR150

Ensembl ID: ENSG00000207782

Description: microRNA 150

Associated with

  • Pre-notch expression and processing
    (R-HSA-1912422)
  • Pre-notch transcription and translation
    (R-HSA-1912408)
  • Signaling by notch
    (R-HSA-157118)
  • Signal transduction
    (R-HSA-162582)
  • Extracellular space
    (GO:0005615)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Positive regulation of cell migration involved in sprouting angiogenesis
    (GO:0090050)
  • Positive regulation of endothelial cell differentiation
    (GO:0045603)
  • Positive regulation of mesodermal cell differentiation
    (GO:1905772)
  • Regulation of vascular endothelial cell proliferation
    (GO:1905562)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0250
    Cell Significance Index: -0.2900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0278
    Cell Significance Index: -0.3400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0287
    Cell Significance Index: -0.3400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0333
    Cell Significance Index: -0.5700
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0402
    Cell Significance Index: -0.3600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0415
    Cell Significance Index: -0.4400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0434
    Cell Significance Index: -0.4800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0487
    Cell Significance Index: -0.6400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0524
    Cell Significance Index: -0.5800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0567
    Cell Significance Index: -0.5100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0580
    Cell Significance Index: -0.5100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0618
    Cell Significance Index: -0.5700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0703
    Cell Significance Index: -0.6200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0904
    Cell Significance Index: -0.9200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0960
    Cell Significance Index: -0.9100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1012
    Cell Significance Index: -0.9400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1048
    Cell Significance Index: -0.9800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2178
    Cell Significance Index: -1.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR150 is a member of the microRNA family, which consists of small, non-coding RNAs (20-25 nucleotides in length) that regulate gene expression post-transcriptionally by binding to messenger RNA (mRNA) and preventing its translation or degrading it. MIR150 is distinct from other microRNAs due to its unique targeting specificity and its involvement in multiple biological pathways. Its expression is tightly regulated, with varying levels detected in different cell types and tissues, suggesting a complex interplay between MIR150 and its target genes. **Pathways and Functions:** MIR150 is involved in several critical biological pathways, including: 1. **Mirna-mediated post-transcriptional gene silencing**: MIR150 regulates the expression of target genes by binding to their 3'-untranslated regions (3'-UTR) and preventing translation or promoting degradation. 2. **Positive regulation of cell migration**: MIR150 promotes cell migration, a crucial process in angiogenesis, by regulating the expression of genes involved in cell adhesion and motility. 3. **Positive regulation of endothelial cell differentiation**: MIR150 regulates the differentiation of endothelial cells, which is essential for vascular development and maintenance. 4. **Positive regulation of mesodermal cell differentiation**: MIR150 promotes the differentiation of mesodermal cells, which gives rise to various cell types, including immune cells and smooth muscle cells. 5. **Regulation of vascular endothelial cell proliferation**: MIR150 regulates the proliferation of vascular endothelial cells, which is critical for angiogenesis and tissue repair. 6. **Signaling by Notch**: MIR150 is involved in the Notch signaling pathway, which is essential for cell fate determination and development. 7. **RISC complex**: MIR150 interacts with the RNA-induced silencing complex (RISC), which is responsible for the degradation of target mRNAs. **Clinical Significance:** Dysregulation of MIR150 has been implicated in various diseases, including: 1. **Immune disorders**: MIR150 has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where its dysregulation can lead to impaired immune function. 2. **Cancer**: MIR150 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma, where it can promote tumor growth and metastasis. 3. **Cardiovascular disease**: MIR150 plays a role in vascular development and maintenance, and its dysregulation can contribute to cardiovascular disease. 4. **Neurological disorders**: MIR150 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation can lead to impaired neuronal function. In conclusion, MIR150 is a multifaceted regulator of immune and vascular development, with its dysregulation contributing to various diseases. Further research is needed to fully understand the mechanisms by which MIR150 regulates gene expression and its clinical significance in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.