Details for: MIR18A

Gene ID: 406953

Symbol: MIR18A

Ensembl ID: ENSG00000283815

Description: microRNA 18a

Associated with

  • Extracellular space
    (GO:0005615)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of cellular response to transforming growth factor beta stimulus
    (GO:1903845)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of extracellular matrix assembly
    (GO:1901202)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of sprouting angiogenesis
    (GO:1903671)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Positive regulation of b cell receptor signaling pathway
    (GO:0050861)
  • Positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
    (GO:1905932)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.1362
    Cell Significance Index: 14.8300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.9205
    Cell Significance Index: 10.8200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.4255
    Cell Significance Index: 8.6600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.3031
    Cell Significance Index: 6.0400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.2778
    Cell Significance Index: 4.1600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0071
    Cell Significance Index: 0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0785
    Cell Significance Index: -15.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3265
    Cell Significance Index: -10.6900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3562
    Cell Significance Index: -3.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4730
    Cell Significance Index: -16.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5075
    Cell Significance Index: -16.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5094
    Cell Significance Index: -8.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6314
    Cell Significance Index: -12.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7265
    Cell Significance Index: -18.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8664
    Cell Significance Index: -18.0800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8898
    Cell Significance Index: -17.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9270
    Cell Significance Index: -20.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0096
    Cell Significance Index: -20.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0941
    Cell Significance Index: -23.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR18A is a 22-nucleotide long miRNA that belongs to the miR-17-92 cluster, which is one of the most well-studied miRNA families. It is highly conserved across species, with high sequence identity among mammals. MIR18A is primarily expressed in cells of the immune system, including lymphoid lineage-restricted progenitor cells, pericytes, and cardiac endothelial cells. Its expression is also detected in other cell types, such as neuronal receptor cells, smooth muscle myoblasts, and fibroblasts of cardiac tissue. **Pathways and Functions:** MIR18A is involved in regulating various cellular processes through its interactions with target mRNAs. Some of its key regulatory pathways include: 1. **Mirna-mediated gene silencing by mRNA destabilization:** MIR18A binds to target mRNAs, leading to their degradation or repression of translation, thereby silencing gene expression. 2. **Mirna-mediated post-transcriptional gene silencing:** MIR18A regulates gene expression by targeting mRNAs that are involved in cell differentiation, proliferation, and survival. 3. **Mrna base-pairing translational repressor activity:** MIR18A can repress translation of target mRNAs by forming base pairs with them, thereby inhibiting protein synthesis. 4. **Negative regulation of cellular response to transforming growth factor beta stimulus:** MIR18A regulates the TGF-β signaling pathway, which is involved in cell growth, differentiation, and survival. 5. **Negative regulation of epithelial to mesenchymal transition:** MIR18A inhibits the EMT process, which is involved in tissue remodeling and cancer progression. **Clinical Significance:** Dysregulation of MIR18A has been implicated in various diseases, including: 1. **Cancer:** MIR18A is downregulated in several types of cancer, including breast, lung, and colon cancer, suggesting its role as a tumor suppressor. 2. **Cardiovascular disorders:** MIR18A is involved in regulating cardiac cell differentiation and survival, and its dysregulation has been implicated in heart failure and arrhythmias. 3. **Autoimmune conditions:** MIR18A regulates immune cell function and is involved in autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, MIR18A is a critical regulator of cellular processes, and its dysregulation has significant implications for human health. Further research is needed to fully understand the mechanisms by which MIR18A regulates cellular processes and to explore its therapeutic potential in various diseases. **Recommendations:** 1. **Future research directions:** Investigate the role of MIR18A in other diseases, such as neurological disorders and metabolic diseases. 2. **Therapeutic applications:** Explore the potential of MIR18A as a therapeutic target for cancer, cardiovascular disorders, and autoimmune conditions. 3. **Mechanistic studies:** Investigate the molecular mechanisms by which MIR18A regulates cellular processes and its interactions with target mRNAs. By understanding the complex regulatory mechanisms of MIR18A, we can develop novel therapeutic strategies to treat various diseases and improve human health.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.