Details for: MIR200C

Gene ID: 406985

Symbol: MIR200C

Ensembl ID: ENSG00000207713

Description: microRNA 200c

Associated with

  • Adherens junctions interactions
    (R-HSA-418990)
  • Cell-cell communication
    (R-HSA-1500931)
  • Cell-cell junction organization
    (R-HSA-421270)
  • Cell junction organization
    (R-HSA-446728)
  • Pre-notch expression and processing
    (R-HSA-1912422)
  • Pre-notch transcription and translation
    (R-HSA-1912408)
  • Regulation of cdh11 expression and function
    (R-HSA-9759475)
  • Regulation of cdh11 mrna translation by micrornas
    (R-HSA-9759811)
  • Regulation of expression and function of type ii classical cadherins
    (R-HSA-9764260)
  • Regulation of homotypic cell-cell adhesion
    (R-HSA-9759476)
  • Signaling by notch
    (R-HSA-157118)
  • Signal transduction
    (R-HSA-162582)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of calcium ion import across plasma membrane
    (GO:1905949)
  • Negative regulation of cell migration involved in sprouting angiogenesis
    (GO:0090051)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of interleukin-33 production
    (GO:0150128)
  • Negative regulation of toll-like receptor 4 signaling pathway
    (GO:0034144)
  • Negative regulation of vascular endothelial growth factor receptor signaling pathway
    (GO:0030948)
  • Negative regulation of voltage-gated calcium channel activity
    (GO:1901386)
  • Positive regulation of endothelial cell differentiation
    (GO:0045603)
  • Positive regulation of mesodermal cell differentiation
    (GO:1905772)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Regulation of cardiac muscle contraction
    (GO:0055117)
  • Regulation of vascular endothelial cell proliferation
    (GO:1905562)
  • Response to amyloid-beta
    (GO:1904645)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 9.14
    Marker Score: 2743
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 7.29
    Marker Score: 2742
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 6.02
    Marker Score: 2667
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 5.54
    Marker Score: 2645
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 3.94
    Marker Score: 2368
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.32
    Marker Score: 5285
  • Cell Name: pericyte (CL0000669)
    Fold Change: 3.14
    Marker Score: 1832
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.75
    Marker Score: 2739
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 2.75
    Marker Score: 2189
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 2.45
    Marker Score: 2738
  • Cell Name: brush cell (CL0002204)
    Fold Change: 2.19
    Marker Score: 1999
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.12
    Marker Score: 2741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.29
    Marker Score: 2093
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 6980
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.93
    Marker Score: 28837
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.91
    Marker Score: 2315
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1656
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1538
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.79
    Marker Score: 2368
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.76
    Marker Score: 4609
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.72
    Marker Score: 4126
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.56
    Marker Score: 2687
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1662
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2
    Marker Score: 3112

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Other Information

**Key Characteristics:** MIR200C is a small non-coding RNA that regulates gene expression post-transcriptionally by binding to target messenger RNAs (mRNAs), thereby inhibiting their translation or stability. Its primary function is to regulate the expression of cell adhesion molecules, such as cadherins, and the Notch signaling pathway. MIR200C has been shown to bind to the 3'-untranslated regions (3'-UTR) of target mRNAs, leading to their degradation or inhibition of translation. **Pathways and Functions:** MIR200C is involved in various signaling pathways, including: 1. **Adherens junctions interactions:** MIR200C regulates the expression of cadherins, which are essential for cell-cell adhesion and tissue structure. 2. **Cell-cell communication:** MIR200C modulates the expression of genes involved in cell signaling, such as the Notch pathway, which regulates cell fate decisions. 3. **Cell junction organization:** MIR200C regulates the expression of genes involved in cell junction formation and maintenance, including desmogleins and desmocollins. 4. **Mirna-mediated gene silencing:** MIR200C uses its miRNA-mediated post-transcriptional gene silencing (PTGS) mechanism to regulate gene expression. 5. **Negative regulation of calcium ion import:** MIR200C regulates calcium ion import across the plasma membrane, which is essential for cellular signaling and function. **Clinical Significance:** Dysregulation of MIR200C has been implicated in various diseases, including: 1. **Cancer:** MIR200C has been shown to be downregulated in several types of cancer, including breast, lung, and colon cancer, and its dysregulation is associated with tumor progression and metastasis. 2. **Cardiovascular disease:** MIR200C has been shown to regulate cardiovascular development and function, and its dysregulation is associated with cardiovascular disease. 3. **Neurodegenerative disorders:** MIR200C has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 4. **Autoimmune diseases:** MIR200C has been shown to regulate immune cell function and has been implicated in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. In conclusion, MIR200C is a crucial regulator of cell adhesion, differentiation, and signaling in tissues. Its dysregulation has significant implications for various diseases, and further research is needed to fully understand its role in human diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.