Details for: MIR200C

Gene ID: 406985

Symbol: MIR200C

Ensembl ID: ENSG00000207713

Description: microRNA 200c

Associated with

  • Adherens junctions interactions
    (R-HSA-418990)
  • Cell-cell communication
    (R-HSA-1500931)
  • Cell-cell junction organization
    (R-HSA-421270)
  • Cell junction organization
    (R-HSA-446728)
  • Pre-notch expression and processing
    (R-HSA-1912422)
  • Pre-notch transcription and translation
    (R-HSA-1912408)
  • Regulation of cdh11 expression and function
    (R-HSA-9759475)
  • Regulation of cdh11 mrna translation by micrornas
    (R-HSA-9759811)
  • Regulation of expression and function of type ii classical cadherins
    (R-HSA-9764260)
  • Regulation of homotypic cell-cell adhesion
    (R-HSA-9759476)
  • Signaling by notch
    (R-HSA-157118)
  • Signal transduction
    (R-HSA-162582)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of calcium ion import across plasma membrane
    (GO:1905949)
  • Negative regulation of cell migration involved in sprouting angiogenesis
    (GO:0090051)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of interleukin-33 production
    (GO:0150128)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of toll-like receptor 4 signaling pathway
    (GO:0034144)
  • Negative regulation of vascular endothelial growth factor receptor signaling pathway
    (GO:0030948)
  • Negative regulation of voltage-gated calcium channel activity
    (GO:1901386)
  • Positive regulation of endothelial cell differentiation
    (GO:0045603)
  • Positive regulation of mesodermal cell differentiation
    (GO:1905772)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Regulation of cardiac muscle contraction
    (GO:0055117)
  • Regulation of vascular endothelial cell proliferation
    (GO:1905562)
  • Response to amyloid-beta
    (GO:1904645)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.0072
    Cell Significance Index: 0.0700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.0024
    Cell Significance Index: 0.0200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0116
    Cell Significance Index: -0.1200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0117
    Cell Significance Index: -0.1300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0120
    Cell Significance Index: -0.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0342
    Cell Significance Index: -1.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0651
    Cell Significance Index: -0.7700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0655
    Cell Significance Index: -0.7300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0664
    Cell Significance Index: -0.8700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0797
    Cell Significance Index: -1.0500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0835
    Cell Significance Index: -0.9900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0947
    Cell Significance Index: -0.9700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0956
    Cell Significance Index: -1.1400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1032
    Cell Significance Index: -1.1000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1144
    Cell Significance Index: -1.1100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1262
    Cell Significance Index: -1.2900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1440
    Cell Significance Index: -1.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MIR200C exhibits several key characteristics that distinguish it from other microRNAs. Firstly, its expression is highly restricted to specific cell types, including intestinal crypt stem cells, lymphoid lineage-restricted progenitor cells, and epithelial cells. This specificity is reflected in its ability to regulate the expression of genes involved in cell-cell adhesion, migration, and differentiation. MIR200C also exhibits a unique ability to regulate the expression of type II classical cadherins, which are essential for maintaining epithelial cell polarity and integrity. **Pathways and Functions** MIR200C is involved in a wide range of cellular processes, including: 1. **Adherens Junctions Interactions**: MIR200C regulates the expression of CDH11, a key component of adherens junctions, which are essential for maintaining epithelial cell polarity and integrity. 2. **Cell-cell Communication**: MIR200C modulates the expression of genes involved in cell-cell communication, including Notch signaling pathways, which are critical for regulating cell fate decisions. 3. **Cell-cell Junction Organization**: MIR200C regulates the expression of genes involved in maintaining epithelial cell polarity and integrity, including CDH1 and CDH4. 4. **MicroRNA-mediated Gene Silencing**: MIR200C exerts its regulatory effects by inhibiting the translation of target mRNAs or destabilizing their expression through mRNA destabilization. 5. **Regulation of Cardiac Muscle Contraction**: MIR200C has been shown to regulate the expression of cardiac muscle contraction-related genes, highlighting its role in cardiovascular development and function. **Clinical Significance** Dysregulation of MIR200C has been implicated in various diseases, including: 1. **Cancer**: MIR200C has been shown to be downregulated in various types of cancer, including breast, lung, and colon cancer, where it plays a role in maintaining epithelial cell polarity and integrity. 2. **Cardiovascular Disease**: MIR200C has been implicated in the regulation of cardiac muscle contraction and has been shown to be downregulated in patients with cardiovascular disease. 3. **Neurological Disorders**: MIR200C has been shown to regulate the expression of genes involved in neuronal development and function, highlighting its potential role in neurological disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). In conclusion, MIR200C is a critical regulator of various cellular processes, including cell-cell adhesion, migration, proliferation, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.