Details for: CT45A6

Gene ID: 541465

Symbol: CT45A6

Ensembl ID: ENSG00000278289

Description: cancer/testis antigen family 45 member A6

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.3632
    Cell Significance Index: 3.8100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.0237
    Cell Significance Index: 0.2800
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.0075
    Cell Significance Index: 0.0800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0018
    Cell Significance Index: -0.0500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0026
    Cell Significance Index: -0.0200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0026
    Cell Significance Index: -0.0200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0027
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0054
    Cell Significance Index: -1.0900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0102
    Cell Significance Index: -0.1300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0104
    Cell Significance Index: -0.1400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0106
    Cell Significance Index: -0.1100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0127
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0147
    Cell Significance Index: -0.0900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0333
    Cell Significance Index: -0.4000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0336
    Cell Significance Index: -0.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0341
    Cell Significance Index: -0.4100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0371
    Cell Significance Index: -0.4500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0407
    Cell Significance Index: -0.4100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0413
    Cell Significance Index: -0.4400
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0466
    Cell Significance Index: -0.4100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0566
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0661
    Cell Significance Index: -0.7000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0916
    Cell Significance Index: -1.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CT45A6 gene belongs to the cancer/testis antigen (CTA) family, a group of genes that are normally expressed in testicular germ cells but are also found in various types of cancer. This gene's expression profile is characterized by its widespread expression in multiple cell types, including non-cancerous cells such as tracheobronchial smooth muscle cells and intestinal epithelial cells. Notably, the CT45A6 gene is also expressed in abnormal cells, suggesting that it may play a role in the development or progression of cancer. **Pathways and Functions:** Despite its relatively limited understanding, research suggests that the CT45A6 gene may be involved in various cellular processes, including cell proliferation, differentiation, and survival. The gene's expression in tracheobronchial smooth muscle cells, for example, may be linked to the regulation of airway tone and responsiveness. Similarly, its expression in intestinal enteroendocrine cells may be involved in the regulation of gut motility and secretion. Further studies are needed to elucidate the specific pathways and functions of the CT45A6 gene. **Clinical Significance:** The CT45A6 gene's expression in cancer cells has sparked interest in its potential as a biomarker for cancer diagnosis and monitoring. Studies have shown that the CT45A6 gene is overexpressed in various types of cancer, including lung, breast, and colon cancer. This suggests that the CT45A6 gene may be involved in the development or progression of cancer, and that it may serve as a valuable target for immunotherapy. Additionally, the CT45A6 gene's expression in non-cancerous cells may provide insights into the development of diseases such as asthma and inflammatory bowel disease. In conclusion, the CT45A6 gene is a fascinating and complex gene that warrants further investigation. Its unique expression profile and potential implications in various diseases make it an attractive target for research and therapeutic intervention. Further studies are needed to elucidate the specific pathways and functions of the CT45A6 gene and to explore its clinical significance in the diagnosis and treatment of diseases. **Recommendations for Future Research:** 1. Elucidate the specific pathways and functions of the CT45A6 gene in normal and cancerous cells. 2. Investigate the role of the CT45A6 gene in the development and progression of various diseases, including cancer, asthma, and inflammatory bowel disease. 3. Explore the potential of the CT45A6 gene as a biomarker for cancer diagnosis and monitoring. 4. Investigate the therapeutic potential of targeting the CT45A6 gene in cancer treatment. By addressing these questions and exploring the clinical significance of the CT45A6 gene, researchers may uncover new insights into the biology of this enigmatic gene and its role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.