Details for: SERTAD4

Gene ID: 56256

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SERTAD4

Ensembl ID: ENSG00000082497

Description: SERTA domain containing 4

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • neural progenitor cell CL0011020
    CSI 5.6
    rCSI 24.63%
    PRS 85.01
  • lung ciliated cell CL1000271
    CSI 3.71
    rCSI 4.29%
    PRS 89.82
  • duct epithelial cell CL0000068
    CSI 3.63
    rCSI 5.3%
    PRS 96.37
  • interneuron CL0000099
    CSI 3.5
    rCSI 7.02%
    PRS 89.73
  • extravillous trophoblast CL0008036
    CSI 3.39
    rCSI 4.19%
    PRS 92.65
  • epithelial cell CL0000066
    CSI 3.32
    rCSI 5.11%
    PRS 83.55
  • enteric smooth muscle cell CL0002504
    CSI 3.31
    rCSI 4.73%
    PRS 93.96
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 3.16
    rCSI 3.65%
    PRS 87.84
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 3.05
    rCSI 3.7%
    PRS 76.88
  • epithelial cell of lung CL0000082
    CSI 2.84
    rCSI 2.35%
    PRS 95.02
  • ionocyte CL0005006
    CSI 2.61
    rCSI 2.79%
    PRS 94.91
  • ciliated epithelial cell CL0000067
    CSI 2.44
    rCSI 2.15%
    PRS 87.16
  • club cell CL0000158
    CSI 2.31
    rCSI 3.38%
    PRS 90.9
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 2.17
    rCSI 2.78%
    PRS 90.93
  • respiratory basal cell CL0002633
    CSI 2.15
    rCSI 2.22%
    PRS 95.21
  • multi-ciliated epithelial cell CL0005012
    CSI 1.96
    rCSI 1.96%
    PRS 89.4
  • chondrocyte CL0000138
    CSI 1.95
    rCSI 3.11%
    PRS 90.72
  • glioblast CL0000030
    CSI 1.84
    rCSI 2.93%
    PRS 88.05
  • basal cell of epidermis CL0002187
    CSI 1.75
    rCSI 3.09%
    PRS 68.96
  • glycinergic amacrine cell CL4030028
    CSI 1.62
    rCSI 4.23%
    PRS 89.07
  • mesenchymal cell CL0008019
    CSI 1.46
    rCSI 3.72%
    PRS 90.45
  • melanocyte of skin CL1000458
    CSI 0.89
    rCSI 1.22%
    PRS 68.72
  • Merkel cell CL0000242
    CSI 0.57
    rCSI 13.31%
    PRS 98.69

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary **[SERTAD4](/details-gene/56256)** (SERTA domain containing 4) is a protein-coding gene located on human chromosome 1. Based on Gene Ontology annotations, it encodes a nuclear protein with a primary molecular function in [protein binding](/details-cell/GO:0005515) ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)). Expression data highlights its significant role in specific cell populations, with its highest significance observed in [neural progenitor cell](/details-cell/CL0011020)s, suggesting a function in neural development. Furthermore, **[SERTAD4](/details-gene/56256)** shows a strong expression signature across various specialized epithelial cells, particularly those of the respiratory system like [lung ciliated cell](/details-cell/CL1000271)s, pointing towards additional roles in epithelial tissue maintenance and function. The gene's initial characterization was part of large-scale cDNA sequencing and chromosome annotation projects ([Link](https://doi.org/10.1038/ng1285), [Link](https://doi.org/10.1038/nature04727)). ## Cellular Roles and Expression Landscape The expression profile of **[SERTAD4](/details-gene/56256)** reveals a highly specific pattern concentrated in developmental and terminally differentiated cell types. **Overall**, the gene's most prominent role is indicated in the nervous system, where it achieves its highest cell significance index (CSI: 5.60) in [neural progenitor cell](/details-cell/CL0011020)s. This finding, combined with its notable significance in [interneuron](/details-cell/CL0000099)s and various [neuroblast](/details-cell/CL0000338) populations, strongly suggests its involvement in processes of neurogenesis, including cell fate determination and differentiation. A second major functional hub for **[SERTAD4](/details-gene/56256)** is within epithelial tissues, especially in the respiratory tract. The gene is a significant marker for [lung ciliated cell](/details-cell/CL1000271)s, [duct epithelial cell](/details-cell/CL0000068)s, [epithelial cell of lung](/details-cell/CL0000082)s, [club cell](/details-cell/CL0000158)s, and [respiratory basal cell](/details-cell/CL0002633)s. This consistent expression across multiple lung epithelial subtypes suggests it may be part of the core transcriptional machinery required for establishing or maintaining the specialized functions of the airway epithelium. Beyond these primary contexts, **[SERTAD4](/details-gene/56256)** also shows significant expression in [extravillous trophoblast](/details-cell/CL0008036)s, implying a potential role in placental development, and in [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203)s, indicating a possible, though less defined, function within the adaptive immune system. ## Pathways and Molecular Function The functional annotation of **[SERTAD4](/details-gene/56256)** is currently limited, providing a broad framework for its cellular activities. Gene Ontology analysis places the protein product within the [nucleus](/details-cell/GO:0005634) ([GO:0005634](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)), and its annotated molecular function is [protein binding](/details-cell/GO:0005515) ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)). This combination of nuclear localization and protein-binding capacity is characteristic of a transcriptional co-regulator or a component of a larger nuclear protein complex. In the context of its high expression in [neural progenitor cell](/details-cell/CL0011020)s, **[SERTAD4](/details-gene/56256)** may function by binding to transcription factors or chromatin-modifying enzymes to regulate the gene expression programs that govern the switch between proliferation and differentiation. Similarly, in specialized cells like [lung ciliated cell](/details-cell/CL1000271)s, it could be involved in regulating the expression of genes essential for ciliogenesis or mucociliary clearance. The specific binding partners and downstream pathways regulated by **[SERTAD4](/details-gene/56256)** remain to be elucidated. ## Research Directions The specific expression pattern of **[SERTAD4](/details-gene/56256)** combined with its limited functional annotation presents several opportunities for future investigation. **Proposed Hypotheses:** 1. Given its high significance in [neural progenitor cell](/details-cell/CL0011020)s and [neuroblast](/details-cell/CL0000031)s, **[SERTAD4](/details-gene/56256)** may function as a nuclear regulator essential for maintaining the multipotent state or guiding lineage commitment during neurogenesis. Its loss would be hypothesized to disrupt normal brain development by causing premature differentiation or a shift in cell fate. 2. The consistent high expression across multiple lung epithelial cell types suggests that **[SERTAD4](/details-gene/56256)** is a key transcriptional component for airway cell function. It is hypothesized to be involved in the terminal differentiation and functional maintenance of these cells, potentially by regulating pathways related to ciliogenesis or secretory functions. 3. The notable expression in [extravillous trophoblast](/details-cell/CL0008036)s suggests that **[SERTAD4](/details-gene/56256)** plays a role in placental development, possibly by regulating the invasive properties of trophoblasts required for proper uterine implantation. **Key Experimental Approach:** To test the hypothesis that **[SERTAD4](/details-gene/56256)** is critical for neural development, an in-vitro differentiation model using human induced pluripotent stem cells (iPSCs) could be employed. A **[SERTAD4](/details-gene/56256)**-knockout iPSC line could be generated using CRISPR-Cas9 technology. Both knockout and isogenic wild-type iPSCs would then be subjected to a directed differentiation protocol to generate neural progenitor cells and mature neurons. The impact of **[SERTAD4](/details-gene/56256)** loss could be assessed through a combination of single-cell RNA sequencing to map changes in differentiation trajectories and immunofluorescence staining for key markers of progenitor (e.g., SOX2, PAX6) and neuronal (e.g., MAP2, TUJ1) identity to quantify differentiation efficiency. **Therapeutic Potential:** The therapeutic potential of **[SERTAD4](/details-gene/56256)** is currently speculative due to its poorly defined function. Its specific expression in progenitor cells could make it a target in developmental diseases or cancers characterized by a de-differentiated state, such as neuroblastoma. However, its expression across several healthy tissues, including lung and immune cells, raises potential concerns for on-target toxicity. As a nuclear protein involved in protein-protein interactions, it is not an ideal target for antibody-based therapies. Future therapeutic strategies would likely involve the development of small molecule inhibitors to disrupt its specific interactions, but this first requires a detailed understanding of its binding partners and downstream effects.

Genular Protein ID: 513819233

Symbol: SRTD4_HUMAN

Name: SERTA domain-containing protein 4

UniProtKB Accession Codes:

Q9NUC0 B2RD32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 356
  • Mass: 39348
  • Checksum: AC08F5241EFECE74
  • Sequence:
    • MTLVLSMNRF CEPIVSEGAA EIAGYQTLWE ADSYGGPSPP GPAQAPLQGD RGAGPPLAGS 
HYRGISNPIT TSKITYFKRK YVEEEDFHPP LSSCSHKTIS IFEERAHILY MSLEKLKFID 
DPEVYLRRSV LINNLMKRIH GEIIMQNNWC FPACSFNGTS AQEWFMAQDC PYRKRPRMAK 
EECEKFHACC FYQECGGHYL NLPLSVNANV GSASTAASSP SASSSSSSSS SSPPLPLPSC 
SRQVDFDVGS ASIYKSDGQI PANEIFVTNV RSLGVQEKAK LNDEKANDDT NRDGGPLSHE 
PVGNDLAFEC KGQFYDYFET GYNERNNVNE SWKKSLRKKE ASPPSNKLCC SKGSKI