Details for: SNORD21

Gene ID: 6083

Symbol: SNORD21

Ensembl ID: ENSG00000206680

Description: small nucleolar RNA, C/D box 21

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0050
    Cell Significance Index: 0.0600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0021
    Cell Significance Index: -0.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0127
    Cell Significance Index: -0.6600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0202
    Cell Significance Index: -0.2200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0324
    Cell Significance Index: -0.3200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0333
    Cell Significance Index: -0.4200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0356
    Cell Significance Index: -0.4800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0467
    Cell Significance Index: -0.6100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0490
    Cell Significance Index: -0.5600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0513
    Cell Significance Index: -0.5500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0526
    Cell Significance Index: -0.6200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0548
    Cell Significance Index: -0.3800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0550
    Cell Significance Index: -0.6300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0551
    Cell Significance Index: -0.6500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0555
    Cell Significance Index: -0.5100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0561
    Cell Significance Index: -0.6600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0565
    Cell Significance Index: -0.6500
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0601
    Cell Significance Index: -0.6600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0618
    Cell Significance Index: -0.6300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0762
    Cell Significance Index: -0.6300
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.1161
    Cell Significance Index: -0.5600
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.2467
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD21 is a C/D box snoRNA, which is characterized by its distinctive secondary structure and the presence of a C/D box motif. snoRNAs are a class of small RNAs that play a pivotal role in RNA processing and modification, including the cleavage of precursor RNAs, the modification of ribosomal RNAs, and the regulation of gene expression. SNORD21 is specifically expressed in various cell types, including plasma cells, pericytes, cardiac endothelial cells, and lymphoid lineage-restricted progenitor cells, highlighting its potential involvement in immunological processes. **Pathways and Functions:** SNORD21 is significantly involved in the regulation of RNA processing and modification, particularly in the context of immunological responses. Research has shown that SNORD21 is involved in the cleavage of precursor RNAs, such as U6 and U17 snRNAs, which are essential for the assembly of the spliceosome, a complex involved in RNA splicing. Additionally, SNORD21 has been implicated in the regulation of gene expression, including the control of immune-related genes. Furthermore, SNORD21 has been shown to interact with various proteins, including nucleophosmin (NPM), which is a key regulator of nucleolar function and RNA processing. **Clinical Significance:** The clinical significance of SNORD21 is an area of active research, with potential implications for the diagnosis and treatment of various diseases. Notably, SNORD21 has been implicated in the pathogenesis of several autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, where aberrant RNA processing and gene expression are thought to play a key role. Additionally, SNORD21 has been shown to be involved in the regulation of immune responses, including the function of plasma cells and lymphoid lineage-restricted progenitor cells. Furthermore, SNORD21 has been implicated in the development of cardiovascular diseases, including cardiac arrhythmias and myocardial infarction, where aberrant RNA processing and gene expression may contribute to disease pathogenesis. In conclusion, SNORD21 is a small nucleolar RNA that plays a crucial role in RNA processing and modification, particularly in the context of immunological responses. Its significant expression in various cell types and its involvement in the regulation of gene expression and immune responses make it an intriguing molecule with potential implications for the diagnosis and treatment of various diseases. Further research is needed to fully elucidate the mechanisms underlying the functions of SNORD21 and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.