Details for: PRR23D2

Gene ID: 100133251

Symbol: PRR23D2

Ensembl ID: ENSG00000255378

Description: proline rich 23 domain containing 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0018
    Cell Significance Index: -0.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0022
    Cell Significance Index: -0.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0022
    Cell Significance Index: -0.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0030
    Cell Significance Index: -0.0700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0033
    Cell Significance Index: -0.0300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0033
    Cell Significance Index: -0.0500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0033
    Cell Significance Index: -0.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0033
    Cell Significance Index: -0.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0035
    Cell Significance Index: -0.0700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0052
    Cell Significance Index: -0.0500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0059
    Cell Significance Index: -0.0600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0063
    Cell Significance Index: -0.0700
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0066
    Cell Significance Index: -0.0600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0068
    Cell Significance Index: -0.0600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0077
    Cell Significance Index: -0.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression profile:** PRR23D2 is significantly expressed in a diverse array of cell types, including glutamatergic neurons, progenitor cells, oligodendrocyte precursor cells, Cajal-Retzius cells, cerebral cortex endothelial cells, epithelial cells, intestinal enteroendocrine cells, microglial cells, and blood vessel endothelial cells. This widespread expression suggests a potential role in regulating cellular processes and interactions across different tissues. 2. **Domain structure:** The PRR23D2 protein contains a characteristic proline-rich 23 domain, which is thought to be involved in protein-protein interactions and binding to specific ligands. 3. **Cell type specificity:** While PRR23D2 is expressed in a wide range of cell types, its expression is often restricted to specific subpopulations within these cells. For example, PRR23D2 is highly expressed in microglial cells, but not in other immune cells. **Pathways and Functions:** 1. **Cell signaling:** PRR23D2 is thought to play a role in cell signaling pathways, including the regulation of neurotransmitter release and synaptic plasticity in glutamatergic neurons. Its expression in Cajal-Retzius cells, which are involved in the development of the cerebral cortex, suggests a potential role in neural development and function. 2. **Immune regulation:** PRR23D2 is also expressed in microglial cells, which are a type of immune cell in the central nervous system. Its expression in these cells suggests a potential role in regulating immune responses and maintaining tissue homeostasis. 3. **Tissue repair:** PRR23D2 is also expressed in oligodendrocyte precursor cells, which are involved in the repair of damaged myelin in the central nervous system. Its expression in these cells suggests a potential role in promoting tissue repair and regeneration. **Clinical Significance:** 1. **Neurological disorders:** The expression of PRR23D2 in glutamatergic neurons, Cajal-Retzius cells, and microglial cells suggests a potential role in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Immune-mediated disorders:** The expression of PRR23D2 in microglial cells and other immune cells suggests a potential role in the pathogenesis of immune-mediated disorders, including autoimmune diseases and inflammatory disorders. 3. **Cancer:** The expression of PRR23D2 in epithelial cells and intestinal enteroendocrine cells suggests a potential role in the development and progression of cancer, particularly in the context of immune evasion and tumor microenvironment modulation. In conclusion, PRR23D2 is a gene of significant interest in the immune system and beyond, with a wide range of expression in various cell types and potential roles in cell signaling, immune regulation, and tissue repair. Further studies are needed to fully elucidate the functions and clinical significance of PRR23D2, but this gene has emerged as a key player in maintaining tissue homeostasis and immune function.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.