Details for: RBMY1F

Gene ID: 159163

Symbol: RBMY1F

Ensembl ID: ENSG00000169800

Description: RNA binding motif protein Y-linked family 1 member F

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: male germ cell (CL0000015)
    Fold Change: 4.17
    Marker Score: 1203
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.76
    Marker Score: 1152
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 2.34
    Marker Score: 1256
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.03
    Marker Score: 1067
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.94
    Marker Score: 1122
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.62
    Marker Score: 1239
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.58
    Marker Score: 877
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.55
    Marker Score: 1026
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.51
    Marker Score: 10033
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.19
    Marker Score: 678
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.12
    Marker Score: 6798
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.12
    Marker Score: 1246
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.08
    Marker Score: 3222
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1.03
    Marker Score: 825
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.02
    Marker Score: 31474
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1
    Marker Score: 1753
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.92
    Marker Score: 2330
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.88
    Marker Score: 1268
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.82
    Marker Score: 4689
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 738
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.6
    Marker Score: 832
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.36
    Marker Score: 2335

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Other Information

**Key Characteristics:** RBMY1F is a member of the RNA binding motif protein family, characterized by its ability to bind to RNA molecules and regulate their processing, splicing, and translation. Its expression is restricted to male germ cells, megakaryocyte-erythroid progenitor cells, and various immune cells, including plasmacytoid dendritic cells, hematopoietic stem cells, mast cells, and precursor B cells. These findings suggest that RBMY1F plays a crucial role in the development and function of these cells, influencing their ability to respond to pathogens and regulate immune responses. **Pathways and Functions:** RBMY1F is involved in several critical signaling pathways, including: 1. **Positive regulation of mRNA splicing via the spliceosome:** RBMY1F interacts with spliceosomal components to regulate the splicing of specific mRNA transcripts, thereby influencing gene expression and cellular differentiation. 2. **Protein binding and RNA binding:** RBMY1F interacts with various proteins and RNA molecules, modulating their interactions and influencing cellular processes. 3. **Identical protein binding and RNA binding:** RBMY1F binds to identical protein partners, regulating their activity and influencing cellular signaling. **Clinical Significance:** The dysregulation of RBMY1F has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** Alterations in RBMY1F expression and function have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** RBMY1F has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role as an oncogene. 3. **Immunodeficiency disorders:** RBMY1F mutations have been associated with immunodeficiency disorders, highlighting its importance in maintaining immune homeostasis. In conclusion, RBMY1F is a critical RNA binding motif protein involved in regulating gene expression, immune cell development, and immune responses. Its dysregulation has been implicated in various immune-related disorders, making it a potential therapeutic target for the treatment of autoimmune diseases, cancer, and immunodeficiency disorders. Further research is needed to elucidate the molecular mechanisms underlying RBMY1F's functions and to explore its therapeutic potential.

Genular Protein ID: 143797715

Symbol: RBY1F_HUMAN

Name: RNA-binding motif protein, Y chromosome, family 1 member F/J

UniProtKB Accession Codes:

Q15415 B2R916

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CDD 1 CTD 2 DMDM 1 DNASU 1 EMBL 6 Ensembl 2 GO 8 Gene3D 1 GeneCards 2 GeneTree 1 Genevisible 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 4 KEGG 2 MANE-Select 2 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SAM 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8269511

Title: A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.

PubMed ID: 8269511

DOI: 10.1016/0092-8674(93)90616-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12815422

Title: The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.

PubMed ID: 12815422

DOI: 10.1038/nature01722

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 496
  • Mass: 55728
  • Checksum: 66AC50828D44E9A8
  • Sequence:
    • MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD 
AKNAAKDMNG TSLHGKAIKV EQAKKPSFQS GGRRRPPASS RNRSPSGSLR SARGSSGGTR 
GWLPSHEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS 
QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY 
RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNHRSSR 
ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD 
EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS HGAPPARGPR MSYGGSTCHA 
YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA YGSSSYVASI 
VDGGESRSEK GDSSRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.