Details for: OR4B2P

Gene ID: 26690

Symbol: OR4B2P

Ensembl ID: ENSG00000255514

Description: olfactory receptor family 4 subfamily B member 2 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.7736
    Cell Significance Index: 7.0000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.5592
    Cell Significance Index: 6.8000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1323
    Cell Significance Index: 1.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1045
    Cell Significance Index: 1.0800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0078
    Cell Significance Index: 0.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0045
    Cell Significance Index: 0.2300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0043
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0187
    Cell Significance Index: -0.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0229
    Cell Significance Index: -0.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0283
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0470
    Cell Significance Index: -0.4400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0721
    Cell Significance Index: -0.9100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0748
    Cell Significance Index: -0.7600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0937
    Cell Significance Index: -0.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1188
    Cell Significance Index: -2.6000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1638
    Cell Significance Index: -1.5600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1780
    Cell Significance Index: -1.5700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1870
    Cell Significance Index: -1.7700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.2060
    Cell Significance Index: -2.3400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2156
    Cell Significance Index: -2.4600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.2582
    Cell Significance Index: -2.8700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3073
    Cell Significance Index: -3.5600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3318
    Cell Significance Index: -4.1900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3385
    Cell Significance Index: -4.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3628
    Cell Significance Index: -3.9500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6288
    Cell Significance Index: -4.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** OR4B2P lacks a functional coding sequence, but its expression in multiple cell types suggests that it may not be entirely devoid of biological activity. 2. **Expression in immune cells:** OR4B2P is significantly expressed in macrophages and stromal cells, which are key players in the immune response. 3. **Expression in neural cells:** The gene is also expressed in neurons, including glutamatergic and Purkinje cells, which are involved in the transmission of signals in the central nervous system. 4. **Tissue specificity:** The expression pattern of OR4B2P varies across different tissues, with some cells showing a more pronounced expression than others. **Pathways and Functions:** 1. **Immune response:** OR4B2P's expression in immune cells suggests that it may play a role in modulating the immune response. The gene's pseudogene status may allow it to interact with other genes or proteins to influence immune cell function. 2. **Neurotransmission:** The expression of OR4B2P in neurons, particularly glutamatergic and Purkinje cells, implies that it may be involved in the transmission of signals within the nervous system. 3. **Cell signaling:** OR4B2P's expression in various cell types suggests that it may be involved in cell signaling pathways, influencing cell behavior and function. **Clinical Significance:** 1. **Immunological disorders:** OR4B2P's expression in immune cells raises the possibility that it may be involved in the pathogenesis of immunological disorders, such as autoimmune diseases or cancer. 2. **Neurological disorders:** The gene's expression in neurons suggests that it may be involved in the development or progression of neurological disorders, such as Parkinson's disease or Alzheimer's disease. 3. **Cancer:** OR4B2P's expression in stromal cells and immune cells may contribute to the development or progression of cancer, particularly in tissues with high levels of immune cell infiltration. 4. **Personalized medicine:** Further research on OR4B2P's functional significance and clinical relevance may lead to the development of personalized therapeutic strategies, tailoring treatments to an individual's specific genetic and molecular profile. In conclusion, the OR4B2P gene, despite its pseudogene status, exhibits a complex expression pattern that suggests it may play a role in the immune system and nervous system. Further research is necessary to elucidate the gene's functional significance and clinical relevance, with potential implications for the development of personalized therapeutic strategies for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.