Details for: SNORD58A

Gene ID: 26791

Symbol: SNORD58A

Ensembl ID: ENSG00000206602

Description: small nucleolar RNA, C/D box 58A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.1424
    Cell Significance Index: 1.6100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0828
    Cell Significance Index: 0.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0193
    Cell Significance Index: 0.2300
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0097
    Cell Significance Index: 0.1200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0055
    Cell Significance Index: 0.0700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.0047
    Cell Significance Index: 0.0500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.0044
    Cell Significance Index: 0.0400
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.0031
    Cell Significance Index: 0.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0022
    Cell Significance Index: -0.6400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0060
    Cell Significance Index: -0.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0234
    Cell Significance Index: -0.2600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0455
    Cell Significance Index: -0.5200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0476
    Cell Significance Index: -0.5100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0493
    Cell Significance Index: -0.6700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0551
    Cell Significance Index: -0.7000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0559
    Cell Significance Index: -0.6400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0591
    Cell Significance Index: -0.7700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0604
    Cell Significance Index: -0.6500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0654
    Cell Significance Index: -0.8700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0736
    Cell Significance Index: -0.5100
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0746
    Cell Significance Index: -0.3600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0765
    Cell Significance Index: -0.9600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0822
    Cell Significance Index: -1.0300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1064
    Cell Significance Index: -1.3300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1179
    Cell Significance Index: -0.9100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1232
    Cell Significance Index: -1.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Function:** SNORD58A is a nucleolar RNA, localized to the nucleolus, where it is involved in RNA processing and modification. 2. **C/D Box Motif:** The gene contains a characteristic C/D box motif, which is a specific sequence found in snoRNAs involved in ribosome biogenesis and RNA modification. 3. **Expression Patterns:** SNORD58A is significantly expressed in plasma cells, pericytes, cardiac endothelial cells, cardiac muscle myoblasts, and other cell types, highlighting its potential role in diverse cellular processes. 4. **Cellular Specificity:** The expression of SNORD58A in specific cell types, such as lymphoid lineage-restricted progenitor cells and retinal pigment epithelial cells, underscores its potential involvement in tissue-specific functions. **Pathways and Functions:** 1. **RNA Processing and Modification:** SNORD58A is involved in RNA processing and modification, specifically in the biogenesis of ribosomal RNA (rRNA) and the regulation of RNA cleavage and modification events. 2. **Ribosome Biogenesis:** The gene's expression in plasma cells and other cell types suggests its involvement in ribosome biogenesis, a critical process for protein synthesis and cellular homeostasis. 3. **Gene Regulation:** SNORD58A may act as a regulator of gene expression by modulating RNA processing and modification events, influencing the expression of target genes involved in various cellular processes. 4. **Cellular Homeostasis:** The gene's expression in cardiac endothelial cells and other cell types implies its involvement in maintaining cellular homeostasis, particularly in the context of tissue-specific functions. **Clinical Significance:** The study of SNORD58A's functions and significance has far-reaching implications for our understanding of various diseases and disorders. As an expert in immunology, I propose the following areas for further research: 1. **Disease Association:** Investigate the potential association of SNORD58A with diseases characterized by aberrant RNA processing and modification, such as autoimmune disorders and cancer. 2. **Therapeutic Targeting:** Explore the possibility of using SNORD58A as a therapeutic target for diseases involving dysregulated RNA processing and modification, such as immunological disorders and cardiovascular diseases. 3. **Cellular Modeling:** Develop cellular models to study the function of SNORD58A in specific cell types and its role in various cellular processes, including RNA processing and modification. In conclusion, SNORD58A is a small nucleolar RNA with diverse cellular expression patterns, involved in RNA processing and modification, ribosome biogenesis, and gene regulation. Further research into its functions and significance will provide valuable insights into the molecular mechanisms underlying various diseases and disorders, ultimately leading to the development of novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.