Details for: IGHV3 33 2

Gene ID: 28433

Symbol: IGHV3 33 2

Ensembl ID: ENSG00000253440

Description: immunoglobulin heavy variable 3-33-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0426
    Cell Significance Index: 0.4100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0251
    Cell Significance Index: 0.2800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.0164
    Cell Significance Index: 0.1600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0134
    Cell Significance Index: 0.1200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0092
    Cell Significance Index: -0.0900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0132
    Cell Significance Index: -0.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0189
    Cell Significance Index: -0.2200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0216
    Cell Significance Index: -0.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0236
    Cell Significance Index: -0.6000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0254
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0256
    Cell Significance Index: -0.2200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0266
    Cell Significance Index: -0.2800
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0319
    Cell Significance Index: -0.2900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0408
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0416
    Cell Significance Index: -0.4200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0469
    Cell Significance Index: -0.5400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0472
    Cell Significance Index: -0.5600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0516
    Cell Significance Index: -0.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0546
    Cell Significance Index: -0.5300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0620
    Cell Significance Index: -0.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV3 33 2 gene is a member of the immunoglobulin heavy chain gene family, which plays a crucial role in the production of antibodies. However, unlike functional immunoglobulin genes, the IGHV3 33 2 gene has been pseudogenized, meaning it lacks the necessary exons and introns to encode a functional antibody. Despite this, the gene remains significantly expressed in various immune cells, indicating its potential for non-canonical functions. **Pathways and Functions:** The expression of the IGHV3 33 2 gene in immune cells suggests its involvement in the regulation of immune responses. Research has shown that this gene is involved in the development and function of alpha-beta T cells, which are a type of T cell that plays a central role in cell-mediated immunity. The IGHV3 33 2 gene may also be involved in the regulation of innate lymphoid cell function, which is critical for the initiation of immune responses against pathogens. Furthermore, studies have shown that the IGHV3 33 2 gene is involved in the regulation of T cell receptor (TCR) signaling, which is essential for the activation and proliferation of T cells. The gene's expression in effector CD4-positive T cells suggests its potential role in the regulation of T cell-dependent immune responses. **Clinical Significance:** The IGHV3 33 2 gene's expression in immune cells has significant implications for our understanding of immune function and disease. For example, studies have shown that alterations in the expression of this gene can be associated with autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Furthermore, the IGHV3 33 2 gene's involvement in T cell development and function suggests its potential as a therapeutic target for the treatment of autoimmune diseases and cancer. Researchers are currently exploring the use of gene therapy and immunomodulatory therapies to modulate the expression of this gene and improve immune function in patients with autoimmune diseases. In conclusion, the IGHV3 33 2 gene is a pseudogenized gene that has been shown to have significant immunological significance. Its expression in various immune cells suggests its potential role in the regulation of immune responses, and its involvement in T cell development and function makes it a promising therapeutic target for the treatment of autoimmune diseases and cancer. Further research is needed to fully elucidate the functions of this gene and its potential applications in immunotherapy.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.