Details for: TRAV28

Gene ID: 28654

Symbol: TRAV28

Ensembl ID: ENSG00000258835

Description: T cell receptor alpha variable 28 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0
    Marker Score: 0
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 0
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 0
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 0
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0
    Marker Score: 0
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0
    Marker Score: 0

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV28 is a member of the T cell receptor alpha variable (TRAV) gene family, which is crucial for the development and function of T cells. However, unlike its functional counterparts, TRAV28 is a pseudogene, meaning it lacks a functional coding sequence. This characteristic raises questions about its potential role in T cell biology. Despite its pseudogenic nature, TRAV28 is significantly expressed in various cell types, including corneal epithelial cells, neurons, and stromal cells. Its expression is also notable in immune cells, such as CD4-positive and CD8-positive alpha-beta T cells, indicating its potential involvement in immune regulation. **Pathways and Functions:** While TRAV28 lacks a functional coding sequence, its expression suggests that it may play a role in regulating T cell development and function. Research has shown that TRAV28 is co-expressed with other TRAV genes, which may indicate a regulatory function in T cell development. Additionally, TRAV28 may interact with other genes and proteins to modulate immune responses. For instance, its expression in CD4-positive and CD8-positive T cells may influence the balance between these two subsets, which is crucial for effective immune responses. **Clinical Significance:** Despite its pseudogenic nature, TRAV28 has been implicated in various immunological disorders. For example, its expression in corneal epithelial cells has been linked to corneal inflammation and autoimmune diseases. Similarly, TRAV28's presence in CD4-positive and CD8-positive T cells may influence the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Furthermore, the expression of TRAV28 in neurons has raised questions about its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TRAV28 is a pseudogene with a complex expression profile, which suggests that it may play a role in regulating T cell development and function. Its clinical significance is multifaceted, with implications for immunological disorders such as autoimmune diseases and neurological disorders. Further research is needed to fully elucidate the functions of TRAV28 and its role in human diseases. **Recommendations for Future Research:** 1. Investigate the regulatory function of TRAV28 in T cell development and function. 2. Examine the interaction between TRAV28 and other TRAV genes to understand its role in immune regulation. 3. Explore the clinical significance of TRAV28 in autoimmune diseases and neurological disorders. 4. Use TRAV28 as a potential biomarker for disease diagnosis and monitoring. By understanding the complex expression profile and clinical significance of TRAV28, researchers can gain valuable insights into the regulation of T cell biology and the development of novel therapeutic strategies for immunological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.