Details for: SNORA62

Gene ID: 6044

Symbol: SNORA62

Ensembl ID: ENSG00000202363

Description: small nucleolar RNA, H/ACA box 62

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.0032
    Cell Significance Index: 0.0400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0002
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0033
    Cell Significance Index: -0.0300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0034
    Cell Significance Index: -0.0300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0049
    Cell Significance Index: -0.0500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0057
    Cell Significance Index: -0.0500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0063
    Cell Significance Index: -0.0400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0068
    Cell Significance Index: -0.0600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0069
    Cell Significance Index: -0.0600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0069
    Cell Significance Index: -0.0700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0070
    Cell Significance Index: -0.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORA62 is a 58-nucleotide long snoRNA that is specifically expressed in a range of cell types, including pericytes, cardiac endothelial cells, cardiac muscle myoblasts, and fibroblasts of cardiac tissue. Its expression is also found in neuronal receptor cells, type A enteroendocrine cells, and acinar cells. Notably, SNORA62 is not expressed in lymphoid lineage-restricted progenitor cells, which highlights its cell-specific regulatory function. **Pathways and Functions:** SNORA62 is involved in the H/ACA box RNA processing pathway, which is crucial for the biogenesis of rRNA and other small RNAs. This pathway involves the interaction of H/ACA snoRNAs with the pre-rRNA and other small RNAs, leading to their processing and maturation. SNORA62 specifically functions in the 5' end processing of rRNA, where it interacts with the H/ACA box helicase and other RNA-binding proteins to facilitate the removal of non-coding regions and the addition of the 5' cap. In addition to its role in RNA processing, SNORA62 has been implicated in regulating cell-specific gene expression. Its expression is tightly regulated in various cell types, suggesting that it plays a crucial role in maintaining cellular identity and function. Furthermore, SNORA62 has been shown to interact with other non-coding RNAs, including microRNAs and long non-coding RNAs, which may contribute to its regulatory functions. **Clinical Significance:** The identification of SNORA62 as a small nucleolar RNA with cell-specific regulatory functions has significant implications for our understanding of human disease. Given its expression in various cell types, SNORA62 may play a role in the development and progression of diseases characterized by altered cellular function, such as cardiovascular disease, cancer, and neurodegenerative disorders. Furthermore, the regulation of SNORA62 expression by environmental and genetic factors may contribute to the development of diseases such as atherosclerosis, where pericytes and endothelial cells are involved. Additionally, the interaction between SNORA62 and other non-coding RNAs may contribute to the development of diseases characterized by aberrant gene expression, such as cancer. In conclusion, SNORA62 is a small nucleolar RNA that plays a crucial role in RNA processing and cell-specific regulation. Its expression in various cell types and its interaction with other non-coding RNAs suggest that it may have significant implications for human disease. Further studies are needed to fully elucidate the functions of SNORA62 and its potential role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.