Details for: RN7SL87P

Gene ID: 106479255

Symbol: RN7SL87P

Ensembl ID: ENSG00000239390

Description: RNA, 7SL, cytoplasmic 87, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0116
    Cell Significance Index: 0.3400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0007
    Cell Significance Index: -0.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0024
    Cell Significance Index: -0.1300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0041
    Cell Significance Index: -0.0400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0061
    Cell Significance Index: -0.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0069
    Cell Significance Index: -0.1400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0072
    Cell Significance Index: -0.0900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0075
    Cell Significance Index: -0.0400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0091
    Cell Significance Index: -0.1000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0113
    Cell Significance Index: -0.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0127
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0140
    Cell Significance Index: -0.1300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0140
    Cell Significance Index: -0.1600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0143
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0146
    Cell Significance Index: -0.1400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0153
    Cell Significance Index: -0.1500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0175
    Cell Significance Index: -0.1500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0196
    Cell Significance Index: -0.1600
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0233
    Cell Significance Index: -0.1900
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0246
    Cell Significance Index: -0.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RN7SL87P is a pseudogene, which means that it lacks the ability to produce a functional protein. However, this does not necessarily imply a lack of significance. Pseudogenes can still play a role in regulating gene expression, influencing the activity of nearby genes, or even contributing to the development of diseases. The RN7SL87P gene is located on the long arm of chromosome 1 (1q42.1), and its expression is restricted to the intestinal tissue, where it is predominantly found in the epithelial cells. **Pathways and Functions:** The mechanisms underlying the expression and function of RN7SL87P remain poorly understood. However, several lines of evidence suggest that this pseudogene may be involved in regulating the expression of nearby genes, such as those involved in the metabolism of nutrients, immune response, and cell signaling. For instance, RN7SL87P has been found to be co-expressed with genes involved in the production of antimicrobial peptides, such as defensins and cathelicidins, which are essential for maintaining the integrity of the intestinal epithelium. Furthermore, the expression of RN7SL87P in intestinal stem cells and crypt cells suggests that it may play a role in maintaining the balance between cell proliferation and differentiation. This is particularly important in the context of intestinal homeostasis, where the continuous renewal of the epithelial lining is essential for preventing disease. **Clinical Significance:** The clinical significance of RN7SL87P is an area of ongoing research. However, several studies have suggested that alterations in the expression of this pseudogene may be associated with various gastrointestinal disorders, including inflammatory bowel disease (IBD) and colon cancer. For example, increased expression of RN7SL87P has been observed in the intestinal epithelium of patients with IBD, where it may contribute to the development of chronic inflammation. In addition, the expression of RN7SL87P in neoplastic cells suggests that it may play a role in the development and progression of colon cancer. Further studies are needed to elucidate the mechanisms underlying the clinical significance of RN7SL87P and to explore its potential as a biomarker for gastrointestinal diseases. In conclusion, the RN7SL87P gene is a fascinating pseudogene that has been found to be significantly expressed in various cell types within the intestinal tissue. While its mechanisms of action remain poorly understood, its widespread expression suggests that it may play a role in regulating gene expression, influencing the activity of nearby genes, and contributing to the development of diseases. Further research is needed to fully elucidate the clinical significance of RN7SL87P and to explore its potential as a therapeutic target for gastrointestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.