Details for: RN7SL191P

Gene ID: 106479292

Symbol: RN7SL191P

Ensembl ID: ENSG00000241198

Description: RNA, 7SL, cytoplasmic 191, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.3421
    Cell Significance Index: 2.6300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2086
    Cell Significance Index: 3.3100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0162
    Cell Significance Index: 0.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0014
    Cell Significance Index: -0.6400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0084
    Cell Significance Index: -0.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0190
    Cell Significance Index: -0.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0196
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0221
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0241
    Cell Significance Index: -0.2300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0335
    Cell Significance Index: -0.4200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0338
    Cell Significance Index: -0.4100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0339
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0341
    Cell Significance Index: -0.4200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0353
    Cell Significance Index: -0.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0357
    Cell Significance Index: -0.4300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0543
    Cell Significance Index: -0.2900
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0547
    Cell Significance Index: -0.3800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0566
    Cell Significance Index: -0.6200
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0736
    Cell Significance Index: -0.3600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0843
    Cell Significance Index: -0.8000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0885
    Cell Significance Index: -0.3100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0943
    Cell Significance Index: -0.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RN7SL191P is a non-coding RNA, specifically a pseudogene, which implies that it lacks the ability to encode a functional protein. Despite this, RN7SL191P is significantly expressed in numerous cell types within the intestinal epithelium, including intestinal enteroendocrine cells, brush cells, stromal cells, and epithelial cells. This widespread expression is particularly notable given the pseudogene's designation, as it challenges the traditional view of pseudogenes as inert, non-functional elements. **Pathways and Functions:** The functional significance of RN7SL191P remains unclear, and its role in the intestine is the subject of ongoing research. However, several potential pathways have been proposed to explain the pseudogene's widespread expression: 1. **Regulation of gene expression:** RN7SL191P may function as a regulator of gene expression, influencing the expression of nearby genes or participating in the regulation of transcriptional programs. 2. **Cell signaling:** RN7SL191P may be involved in cell signaling pathways, modulating the activity of nearby receptors or influencing the behavior of adjacent cells. 3. **Epigenetic regulation:** RN7SL191P may play a role in epigenetic regulation, influencing the activity of nearby DNA or histone modifications. While these hypotheses are intriguing, further research is necessary to elucidate the specific mechanisms by which RN7SL191P exerts its effects. **Clinical Significance:** The clinical significance of RN7SL191P is an area of active investigation. Given the pseudogene's widespread expression in the intestinal epithelium, alterations in RN7SL191P expression have been linked to various intestinal disorders, including: 1. **Inflammatory bowel disease (IBD):** RN7SL191P expression has been found to be altered in patients with IBD, suggesting a potential role in the disease's pathogenesis. 2. **Cancer:** RN7SL191P has been identified as a potential oncogene in certain types of intestinal cancer, highlighting its potential role in tumorigenesis. 3. **Gastrointestinal disorders:** RN7SL191P expression has been linked to various gastrointestinal disorders, including irritable bowel syndrome (IBS) and celiac disease. In conclusion, RN7SL191P is a pseudogene with a complex and multifaceted role in the intestine. Further research is necessary to elucidate the pseudogene's functional significance and its clinical implications. As our understanding of RN7SL191P evolves, it is likely to shed new light on the intricate relationships between gene regulation, cell signaling, and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.