Details for: RNU6 163P

Gene ID: 106479638

Symbol: RNU6 163P

Ensembl ID: ENSG00000207124

Description: RNA, U6 small nuclear 163, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0381
    Cell Significance Index: 0.4500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0304
    Cell Significance Index: -0.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0420
    Cell Significance Index: -2.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0482
    Cell Significance Index: -2.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0599
    Cell Significance Index: -1.7600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0764
    Cell Significance Index: -0.7800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1263
    Cell Significance Index: -1.2200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1389
    Cell Significance Index: -1.6100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1719
    Cell Significance Index: -1.6100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1897
    Cell Significance Index: -2.0800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1936
    Cell Significance Index: -2.3000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1938
    Cell Significance Index: -1.5700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2434
    Cell Significance Index: -2.2700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2606
    Cell Significance Index: -2.6900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2676
    Cell Significance Index: -3.2600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2704
    Cell Significance Index: -3.2600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2964
    Cell Significance Index: -2.5900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3133
    Cell Significance Index: -3.6000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.3198
    Cell Significance Index: -3.3100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3224
    Cell Significance Index: -3.7900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3235
    Cell Significance Index: -2.8500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3709
    Cell Significance Index: -4.8400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3782
    Cell Significance Index: -4.7700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.3994
    Cell Significance Index: -4.1900
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.3997
    Cell Significance Index: -4.2300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4337
    Cell Significance Index: -4.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RNU6 163P gene is a pseudogene, meaning it lacks the capacity to encode a protein. Despite this, it exhibits significant expression in numerous cell types, including intestinal enteroendocrine cells, fibroblasts, macrophages, and epithelial cells. Its widespread expression is a testament to the gene's potential regulatory or functional role in these cells. Notably, the RNU6 163P gene is also expressed in abnormal and neoplastic cells, suggesting its involvement in disease processes. **Pathways and Functions:** The RNU6 163P gene's expression patterns and cellular localization suggest its involvement in various cellular processes. One possible pathway is the regulation of gene expression, where the RNU6 163P gene may act as a non-coding RNA to modulate the expression of nearby genes. Additionally, its expression in immune cells, such as macrophages and monocytes, may indicate a role in the regulation of immune responses. Furthermore, the RNU6 163P gene may be involved in the maintenance of epithelial integrity, given its expression in goblet cells and intestinal epithelial cells. Its expression in fibroblasts and absorptive cells may also suggest a role in tissue homeostasis and wound healing. **Clinical Significance:** The RNU6 163P gene's expression in neoplastic cells and its potential role in disease pathogenesis make it an interesting candidate for further investigation. Cancer research has shown that pseudogenes can act as oncogenes or tumor suppressors, and the RNU6 163P gene's expression in abnormal cells may indicate its involvement in tumorigenesis. Moreover, the RNU6 163P gene's expression in immune cells may have implications for immune-related disorders, such as autoimmune diseases or immunodeficiencies. Further studies are needed to elucidate the gene's functional role in these contexts. In conclusion, the RNU6 163P gene is a complex pseudogene with significant expression patterns and potential functional implications. Further research is necessary to fully understand its role in immunology and disease pathogenesis, but its unique characteristics make it an intriguing candidate for investigation. **Potential Research Directions:** 1. Investigate the RNU6 163P gene's role in immune responses and immune-related disorders. 2. Explore the gene's potential regulatory function in gene expression and cellular processes. 3. Examine the gene's expression patterns in different disease states, including cancer and autoimmune diseases. 4. Investigate the gene's potential as a biomarker for disease diagnosis or prognosis. By addressing these research directions, we can gain a deeper understanding of the RNU6 163P gene's role in immunology and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.