Details for: IGKV2D 18

Gene ID: 28888

Symbol: IGKV2D 18

Ensembl ID: ENSG00000254220

Description: immunoglobulin kappa variable 2D-18 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.08
    Marker Score: 71
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.03
    Marker Score: 39
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2D18 is a pseudogene, meaning that it has undergone mutations that render it non-functional and unable to produce a protein. Despite its pseudogenous status, IGKV2D18 is significantly expressed in multiple B cell populations, including IgA plasma cells, plasmablasts, IgG plasma cells, plasma cells, precursor B cells, B cells, immature B cells, memory B cells, and naive B cells. This widespread expression suggests that IGKV2D18 may play a role in regulating B cell development, differentiation, or function. **Pathways and Functions:** The exact mechanisms by which IGKV2D18 influences B cell development and function are not fully understood. However, several hypotheses have been proposed: 1. **Regulation of B cell receptor signaling:** IGKV2D18 may modulate B cell receptor signaling, influencing the activation, proliferation, and differentiation of B cells. 2. **Influence on gene expression:** IGKV2D18 may interact with other regulatory elements to regulate the expression of genes involved in B cell development and function. 3. **Role in B cell differentiation:** IGKV2D18 may contribute to the differentiation of B cells into plasma cells, a process crucial for the production of antibodies. **Clinical Significance:** While the clinical significance of IGKV2D18 is still unclear, its expression in various B cell populations suggests potential implications in several disease contexts: 1. **Immunodeficiency disorders:** IGKV2D18 may play a role in the development of immunodeficiency disorders, such as X-linked agammaglobulinemia, where B cell development is impaired. 2. **Autoimmune diseases:** The dysregulation of IGKV2D18 may contribute to the development of autoimmune diseases, such as rheumatoid arthritis, where B cells are involved in disease pathology. 3. **Cancer:** IGKV2D18 may be involved in the development or progression of B cell-related cancers, such as Burkitt lymphoma. In conclusion, the IGKV2D18 gene, despite its pseudogenous status, has significant implications for our understanding of B cell development and function. Further research is necessary to elucidate the exact mechanisms by which IGKV2D18 influences B cell biology and to explore its potential role in various disease contexts.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.