Details for: IGKV2D 18

Gene ID: 28888

Symbol: IGKV2D 18

Ensembl ID: ENSG00000254220

Description: immunoglobulin kappa variable 2D-18 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0195
    Cell Significance Index: 0.1300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0073
    Cell Significance Index: -0.1000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0097
    Cell Significance Index: -0.1100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0098
    Cell Significance Index: -0.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0108
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0129
    Cell Significance Index: -0.1200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0140
    Cell Significance Index: -0.1600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0159
    Cell Significance Index: -0.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0663
    Cell Significance Index: -0.8600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0881
    Cell Significance Index: -0.8200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0939
    Cell Significance Index: -0.8000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1321
    Cell Significance Index: -1.1800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1401
    Cell Significance Index: -1.3000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1457
    Cell Significance Index: -1.5700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1701
    Cell Significance Index: -1.8100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1852
    Cell Significance Index: -1.9500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.2040
    Cell Significance Index: -1.9300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2089
    Cell Significance Index: -2.0100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2106
    Cell Significance Index: -1.9700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2154
    Cell Significance Index: -1.9700
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.2169
    Cell Significance Index: -1.9200
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.2231
    Cell Significance Index: -1.5800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2353
    Cell Significance Index: -2.7800
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.2404
    Cell Significance Index: -2.1000
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.2585
    Cell Significance Index: -1.9800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2701
    Cell Significance Index: -2.7600
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.4175
    Cell Significance Index: -2.0900
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.4224
    Cell Significance Index: -2.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2D18 is a pseudogene, meaning that it has undergone mutations that render it non-functional and unable to produce a protein. Despite its pseudogenous status, IGKV2D18 is significantly expressed in multiple B cell populations, including IgA plasma cells, plasmablasts, IgG plasma cells, plasma cells, precursor B cells, B cells, immature B cells, memory B cells, and naive B cells. This widespread expression suggests that IGKV2D18 may play a role in regulating B cell development, differentiation, or function. **Pathways and Functions:** The exact mechanisms by which IGKV2D18 influences B cell development and function are not fully understood. However, several hypotheses have been proposed: 1. **Regulation of B cell receptor signaling:** IGKV2D18 may modulate B cell receptor signaling, influencing the activation, proliferation, and differentiation of B cells. 2. **Influence on gene expression:** IGKV2D18 may interact with other regulatory elements to regulate the expression of genes involved in B cell development and function. 3. **Role in B cell differentiation:** IGKV2D18 may contribute to the differentiation of B cells into plasma cells, a process crucial for the production of antibodies. **Clinical Significance:** While the clinical significance of IGKV2D18 is still unclear, its expression in various B cell populations suggests potential implications in several disease contexts: 1. **Immunodeficiency disorders:** IGKV2D18 may play a role in the development of immunodeficiency disorders, such as X-linked agammaglobulinemia, where B cell development is impaired. 2. **Autoimmune diseases:** The dysregulation of IGKV2D18 may contribute to the development of autoimmune diseases, such as rheumatoid arthritis, where B cells are involved in disease pathology. 3. **Cancer:** IGKV2D18 may be involved in the development or progression of B cell-related cancers, such as Burkitt lymphoma. In conclusion, the IGKV2D18 gene, despite its pseudogenous status, has significant implications for our understanding of B cell development and function. Further research is necessary to elucidate the exact mechanisms by which IGKV2D18 influences B cell biology and to explore its potential role in various disease contexts.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.