Details for: MIRLET7G

Gene ID: 406890

Symbol: MIRLET7G

Ensembl ID: ENSG00000199150

Description: microRNA let-7g

Associated with

  • Cellular response to glucose stimulus
    (GO:0071333)
  • Extracellular space
    (GO:0005615)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of leukocyte adhesion to vascular endothelial cell
    (GO:1904995)
  • Negative regulation of smad protein signal transduction
    (GO:0060392)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0183
    Cell Significance Index: 0.3800
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.0177
    Cell Significance Index: 0.1900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.0117
    Cell Significance Index: 0.1100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0060
    Cell Significance Index: 0.0700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.0003
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0069
    Cell Significance Index: -0.0900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0088
    Cell Significance Index: -0.1100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0089
    Cell Significance Index: -0.1100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0103
    Cell Significance Index: -0.1100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0104
    Cell Significance Index: -0.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0130
    Cell Significance Index: -0.1500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0131
    Cell Significance Index: -0.1100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0131
    Cell Significance Index: -0.1500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0134
    Cell Significance Index: -0.1500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0135
    Cell Significance Index: -0.1500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0145
    Cell Significance Index: -0.1900
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0195
    Cell Significance Index: -0.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **MicroRNA structure and function**: MIRLET7G is a 22-nucleotide long microRNA that is involved in the regulation of gene expression through post-transcriptional mechanisms, including mRNA degradation and translational repression. 2. **Targeting genes**: MIRLET7G targets various genes involved in cellular processes, including cell migration, inflammation, and angiogenesis, thereby modulating their expression levels. 3. **Cellular expression**: MIRLET7G is expressed in multiple cell types, including ependymal cells, enteroendocrine cells, neurons, smooth muscle cells, pericytes, memory B cells, goblet cells, endothelial cells, and cardiac endothelial cells. **Pathways and Functions:** 1. **Cellular response to glucose stimulus**: MIRLET7G regulates glucose response by targeting genes involved in glycolysis and gluconeogenesis. 2. **Negative regulation of cell migration**: MIRLET7G inhibits cell migration by targeting genes involved in the migration process. 3. **Negative regulation of inflammatory response**: MIRLET7G regulates the inflammatory response by targeting genes involved in inflammation. 4. **Negative regulation of leukocyte adhesion to vascular endothelial cell**: MIRLET7G inhibits leukocyte adhesion by targeting genes involved in adhesion. 5. **Negative regulation of smad protein signal transduction**: MIRLET7G regulates smad protein signal transduction by targeting genes involved in the signaling pathway. 6. **Negative regulation of transforming growth factor beta receptor signaling pathway**: MIRLET7G inhibits the transforming growth factor beta receptor signaling pathway by targeting genes involved in the pathway. 7. **Positive regulation of angiogenesis**: MIRLET7G promotes angiogenesis by targeting genes involved in the process. 8. **RISC complex**: MIRLET7G is part of the RNA-induced silencing complex (RISC), which is involved in the regulation of gene expression. **Clinical Significance:** 1. **Cancer**: MIRLET7G has been implicated in cancer development and progression, including colorectal, breast, and lung cancers. 2. **Inflammatory disorders**: MIRLET7G has been implicated in inflammatory disorders, including rheumatoid arthritis and atherosclerosis. 3. **Cardiovascular diseases**: MIRLET7G has been implicated in cardiovascular diseases, including atherosclerosis and cardiac dysfunction. 4. **Neurological disorders**: MIRLET7G has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, MIRLET7G plays a crucial role in regulating various cellular processes, including glucose response, cell migration, inflammation, and angiogenesis. The dysregulation of MIRLET7G has been implicated in various diseases, including cancer, inflammatory disorders, and cardiovascular diseases. Further research is needed to fully understand the role of MIRLET7G in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.