Details for: SSX4B

Gene ID: 548313

Symbol: SSX4B

Ensembl ID: ENSG00000269791

Description: SSX family member 4B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.5
    Marker Score: 1572
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.84
    Marker Score: 1573
  • Cell Name: mast cell (CL0000097)
    Fold Change: 2.11
    Marker Score: 1221
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.91
    Marker Score: 3288
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.6
    Marker Score: 1790
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1.42
    Marker Score: 1129
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.41
    Marker Score: 1573
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.36
    Marker Score: 1217
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.34
    Marker Score: 1573
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.29
    Marker Score: 1224
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.08
    Marker Score: 7159
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.96
    Marker Score: 29665
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.94
    Marker Score: 859
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.89
    Marker Score: 864
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.89
    Marker Score: 2267
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.79
    Marker Score: 4496
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.79
    Marker Score: 2354
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.78
    Marker Score: 4741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1206
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.55
    Marker Score: 1565
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.49
    Marker Score: 1573
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.19
    Marker Score: 1573
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.16
    Marker Score: 1573
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.07
    Marker Score: 1573
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.03
    Marker Score: 1573

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Other Information

**Key Characteristics:** 1. **Expression Pattern**: SSX4B is expressed in a wide range of cell types, including immune cells such as T cells, plasma cells, and macrophages, as well as epithelial cells of the lung alveoli and intestinal enteroendocrine cells. 2. **Protein Structure**: The SSX4B gene encodes for the SSX4 protein, which belongs to the SSX family of proteins that regulate transcription and cellular development. 3. **Cellular Localization**: The SSX4 protein is likely to be localized in the nucleus, where it regulates DNA-templated transcription. **Pathways and Functions:** 1. **Regulation of DNA-templated transcription**: SSX4B plays a crucial role in the regulation of DNA-templated transcription, a process that is essential for the expression of genes involved in cellular development and differentiation. 2. **Cellular development and differentiation**: SSX4B is involved in the regulation of cellular development and differentiation, particularly in immune cells such as T cells and plasma cells. 3. **Apoptosis regulation**: SSX4B has been implicated in the regulation of apoptosis, a process that is crucial for the elimination of damaged or unwanted cells. **Clinical Significance:** 1. **Immunological disorders**: Abnormal expression or function of SSX4B has been implicated in various immunological disorders, including autoimmune diseases and lymphoproliferative disorders. 2. **Cancer**: SSX4B has been found to be overexpressed in certain types of cancer, including lung cancer and lymphoma, highlighting its potential role in tumorigenesis. 3. **Infectious diseases**: SSX4B may play a role in the regulation of immune responses to infectious diseases, such as HIV and tuberculosis. In conclusion, SSX4B is a gene that plays a critical role in the regulation of transcription and cellular development, particularly in immune cells and epithelial cells. Its dysregulation has been implicated in various immunological disorders and cancers, highlighting the need for further research into its clinical significance.

Genular Protein ID: 4265924823

Symbol: SSX4_HUMAN

Name: Protein SSX4

UniProtKB Accession Codes:

O60224 A8MYD4 B2RPE3 Q3SYD4 Q5JQZ0 Q9UJU9

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 4 CTD 2 ChiTaRS 2 DNASU 1 DisGeNET 2 EMBL 7 Ensembl 4 GO 2 GeneCards 2 GeneTree 1 GeneWiki 1 Genevisible 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 5 KEGG 2 MANE-Select 2 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 6 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9378559

Title: SSX: a multigene family with several members transcribed in normal testis and human cancer.

PubMed ID: 9378559

DOI: 10.1002/(sici)1097-0215(19970917)72:6<965::aid-ijc8>3.0.co;2-n

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 188
  • Mass: 21858
  • Checksum: 4ACA2A8737507AE5
  • Sequence:
    • MNGDDAFARR PRDDAQISEK LRKAFDDIAK YFSKKEWEKM KSSEKIVYVY MKLNYEVMTK 
LGFKVTLPPF MRSKRAADFH GNDFGNDRNH RNQVERPQMT FGSLQRIFPK IMPKKPAEEE 
NGLKEVPEAS GPQNDGKQLC PPGNPSTLEK INKTSGPKRG KHAWTHRLRE RKQLVVYEEI 
SDPEEDDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.