Details for: RNA5SP130

Gene ID: 106478995

Symbol: RNA5SP130

Ensembl ID: ENSG00000201301

Description: RNA, 5S ribosomal pseudogene 130

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3684
    Cell Significance Index: 3.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1367
    Cell Significance Index: 1.9500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0381
    Cell Significance Index: 0.4300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0343
    Cell Significance Index: 0.3700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.0022
    Cell Significance Index: 0.0200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.0900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0032
    Cell Significance Index: -0.0800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0069
    Cell Significance Index: -0.0600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0084
    Cell Significance Index: -0.0500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0099
    Cell Significance Index: -0.0900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0104
    Cell Significance Index: -0.0800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0108
    Cell Significance Index: -0.0700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0127
    Cell Significance Index: -0.0800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0168
    Cell Significance Index: -0.2100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0186
    Cell Significance Index: -0.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0244
    Cell Significance Index: -0.3000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0348
    Cell Significance Index: -0.4400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0359
    Cell Significance Index: -0.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The RNA5SP130 gene is a pseudogene, meaning it lacks a functional coding sequence. However, it is still capable of regulating gene expression through various mechanisms. One possible explanation for its functional role is that RPS5SP130 interacts with other non-coding RNAs or proteins to modulate gene expression. The gene is expressed in a wide range of cell types within the intestinal epithelium, including intestinal epithelial cells, goblet cells, and stem cells. This widespread expression suggests that RPS5SP130 plays a critical role in maintaining intestinal homeostasis. **Pathways and Functions** The exact pathways and functions of the RNA5SP130 gene are not fully understood. However, several studies suggest that RPS5SP130 is involved in regulating gene expression through mechanisms such as: 1. **Non-coding RNA-mediated gene regulation**: RPS5SP130 may interact with other non-coding RNAs to modulate gene expression. For example, it could influence the expression of nearby genes or regulate the activity of transcription factors. 2. **Epigenetic regulation**: RPS5SP130 may also influence epigenetic marks, such as DNA methylation or histone modification, to regulate gene expression. 3. **Stem cell maintenance**: RPS5SP130 may play a role in maintaining stem cell homeostasis within the intestinal crypt. This could involve regulating the expression of stem cell-specific genes or influencing the activity of stem cell transcription factors. **Clinical Significance** The RNA5SP130 gene has significant clinical implications, particularly in the context of intestinal diseases. The gene's expression in neoplastic cells and abnormal cells suggests that RPS5SP130 may be involved in the development or progression of intestinal cancer. Further studies are needed to fully understand the role of RPS5SP130 in intestinal disease and to explore its potential as a biomarker or therapeutic target. In addition, the gene's expression in stem cells and goblet cells suggests that RPS5SP130 may play a role in maintaining intestinal homeostasis and preventing disease. Further research is needed to elucidate the mechanisms by which RPS5SP130 regulates gene expression and to explore its potential as a therapeutic target for intestinal diseases. **Conclusion** The RNA5SP130 gene is a complex player in intestinal homeostasis and disease. Its expression in various cell types within the intestinal epithelium suggests that RPS5SP130 plays a critical role in regulating gene expression and maintaining intestinal homeostasis. Further studies are needed to fully understand the mechanisms by which RPS5SP130 regulates gene expression and to explore its potential as a biomarker or therapeutic target for intestinal diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.