Details for: RN7SL147P

Gene ID: 106479274

Symbol: RN7SL147P

Ensembl ID: ENSG00000263988

Description: RNA, 7SL, cytoplasmic 147, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.0328
    Cell Significance Index: 0.2500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0117
    Cell Significance Index: 0.0900
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0044
    Cell Significance Index: -0.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0050
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0050
    Cell Significance Index: -0.0400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0063
    Cell Significance Index: -0.0400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0090
    Cell Significance Index: -0.0800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0113
    Cell Significance Index: -0.1200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0134
    Cell Significance Index: -0.1400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0145
    Cell Significance Index: -0.0800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0229
    Cell Significance Index: -0.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0237
    Cell Significance Index: -0.2600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0240
    Cell Significance Index: -0.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0246
    Cell Significance Index: -0.2900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0267
    Cell Significance Index: -0.2400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0271
    Cell Significance Index: -0.1700
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0285
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0299
    Cell Significance Index: -0.2500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0315
    Cell Significance Index: -0.2800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0346
    Cell Significance Index: -0.2400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0360
    Cell Significance Index: -0.2100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0377
    Cell Significance Index: -0.3100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0423
    Cell Significance Index: -0.2800
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0587
    Cell Significance Index: -0.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RN7SL147P is a cytoplasmic pseudogene, meaning it lacks the ability to self-replicate and is often the result of gene duplication and subsequent non-functionalization. Its expression is significantly observed in several cell types, including intestinal enteroendocrine cells, brush cells, intestinal epithelial cells, goblet cells, and their progenitor cells. This widespread expression suggests that RN7SL147P may play a role in regulating cellular processes, particularly in the context of intestinal homeostasis. **Pathways and Functions:** While the exact mechanisms of RN7SL147P are unclear, research suggests that this pseudogene may be involved in regulating cellular signaling pathways, including those related to cell proliferation, differentiation, and survival. Specifically, RN7SL147P may interact with other ncRNAs to modulate the activity of key transcription factors, such as STAT3 and NF-κB, which are crucial for maintaining intestinal epithelial homeostasis. Furthermore, RN7SL147P may also influence the expression of genes involved in the Wnt/β-catenin pathway, a key regulator of cellular proliferation and differentiation. **Clinical Significance:** The expression of RN7SL147P in various cell types, including neoplastic cells, highlights its potential role in the development and progression of intestinal diseases. Alterations in RN7SL147P expression have been implicated in several human disorders, including colorectal cancer, inflammatory bowel disease (IBD), and celiac disease. In the context of IBD, RN7SL147P may play a role in regulating the immune response and maintaining intestinal epithelial barrier function. Its dysregulation may contribute to the development of chronic inflammation and tissue damage characteristic of IBD. Furthermore, RN7SL147P may also serve as a biomarker for the diagnosis and monitoring of intestinal diseases, given its widespread expression in normal and diseased tissues. In conclusion, RN7SL147P is a complex pseudogene with far-reaching implications for our understanding of intestinal health and disease. Further research is necessary to elucidate the mechanisms by which RN7SL147P regulates cellular processes and to explore its potential as a therapeutic target for the treatment of intestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.