Details for: SNORD49A

Gene ID: 26800

Symbol: SNORD49A

Ensembl ID: ENSG00000277370

Description: small nucleolar RNA, C/D box 49A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.1340
    Cell Significance Index: 1.5100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.1155
    Cell Significance Index: 1.0200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.0219
    Cell Significance Index: 0.2200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0208
    Cell Significance Index: 0.2500
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.0075
    Cell Significance Index: 0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0010
    Cell Significance Index: -0.2700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0147
    Cell Significance Index: -0.1600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0196
    Cell Significance Index: -0.1800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0204
    Cell Significance Index: -0.2400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0224
    Cell Significance Index: -0.2600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0240
    Cell Significance Index: -0.2600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0261
    Cell Significance Index: -0.2800
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.0276
    Cell Significance Index: -0.2600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0282
    Cell Significance Index: -0.3300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0291
    Cell Significance Index: -0.3800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0296
    Cell Significance Index: -0.4000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0341
    Cell Significance Index: -0.3900
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0350
    Cell Significance Index: -0.4000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0428
    Cell Significance Index: -0.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0540
    Cell Significance Index: -0.6400
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0582
    Cell Significance Index: -0.2800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0642
    Cell Significance Index: -0.4500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0908
    Cell Significance Index: -1.1400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1187
    Cell Significance Index: -1.4800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1338
    Cell Significance Index: -1.4400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1435
    Cell Significance Index: -1.8000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1954
    Cell Significance Index: -1.6100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2243
    Cell Significance Index: -1.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD49A is a small nucleolar RNA (sRNA) with a C/D box motif, which is a characteristic feature of sRNAs involved in RNA processing and modification. Its expression profile, with significant presence in plasma cells, pericytes, and cardiac cells, suggests a specialized function in these cell types. The C/D box motif is crucial for the binding of SNORD49A to specific RNA processing factors, enabling its involvement in the regulation of RNA processing events. **Pathways and Functions:** SNORD49A is primarily implicated in the following pathways: 1. **RNA Processing:** SNORD49A is involved in the regulation of RNA processing events, including the modification of rRNA, tRNA, and other RNAs. Its C/D box motif enables it to interact with RNA processing factors, influencing the 2'-O-methylation of rRNA and the 5'-methylthioadenosine modification of tRNA. 2. **Cellular Differentiation:** SNORD49A is expressed in various cell types, including immune cells, suggesting its involvement in cellular differentiation. Its presence in cardiac endothelial cells and smooth muscle myoblasts indicates a role in the development and maintenance of these cell types. 3. **Immune Regulation:** SNORD49A's expression in plasma cells and immune cells suggests a potential role in immune regulation. Its involvement in RNA processing events may influence the production of cytokines and other immune-related molecules. **Clinical Significance:** The study of SNORD49A has significant implications for our understanding of immune regulation, cellular differentiation, and RNA processing. Dysregulation of SNORD49A expression has been implicated in various diseases, including: 1. **Immune-related disorders:** Alterations in SNORD49A expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cardiovascular disease:** SNORD49A's role in cardiac endothelial cell differentiation and maintenance may contribute to the development of cardiovascular disease. 3. **Cancer:** SNORD49A's involvement in RNA processing events may influence the production of oncogenic proteins, contributing to cancer development. In conclusion, SNORD49A is a complex RNA molecule with significant implications for our understanding of RNA processing, cellular differentiation, and immune regulation. Further research is necessary to elucidate the precise mechanisms by which SNORD49A influences these processes and to explore its potential therapeutic applications in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.