Details for: TRAJ61

Gene ID: 28694

Symbol: TRAJ61

Ensembl ID: ENSG00000211831

Description: T cell receptor alpha joining 61 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0023
    Cell Significance Index: -0.8200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0127
    Cell Significance Index: -0.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0332
    Cell Significance Index: -1.0900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0367
    Cell Significance Index: -0.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0480
    Cell Significance Index: -0.8300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0606
    Cell Significance Index: -1.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0640
    Cell Significance Index: -1.2800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0818
    Cell Significance Index: -1.0300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0890
    Cell Significance Index: -1.0100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0983
    Cell Significance Index: -1.1600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0999
    Cell Significance Index: -1.0100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1083
    Cell Significance Index: -1.2000
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1101
    Cell Significance Index: -1.2100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1133
    Cell Significance Index: -1.2700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1148
    Cell Significance Index: -1.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1186
    Cell Significance Index: -1.4000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1263
    Cell Significance Index: -1.0800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1347
    Cell Significance Index: -1.2600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1361
    Cell Significance Index: -1.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1371
    Cell Significance Index: -1.3200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1382
    Cell Significance Index: -1.3000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1392
    Cell Significance Index: -1.3200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1409
    Cell Significance Index: -1.2200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1412
    Cell Significance Index: -1.3100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1472
    Cell Significance Index: -1.3100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1594
    Cell Significance Index: -1.4800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1655
    Cell Significance Index: -1.4600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2808
    Cell Significance Index: -1.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ61, also known as non-functional T cell receptor alpha joining 61, is a gene that does not encode a functional T cell receptor alpha joining domain. This domain is crucial for the proper assembly and function of T cell receptors (TCRs), which are essential for recognizing and responding to antigens. The absence of a functional TRAJ61 protein suggests that this gene may not play a critical role in T cell development or function. Interestingly, TRAJ61 is significantly expressed in various T cell subsets, including CD4-positive, alpha-beta thymocytes, T cells, CD4-positive helper T cells, and exhausted T cells. This widespread expression highlights the importance of TRAJ61 in the development and maintenance of T cells, even if it does not contribute to their functional ability. **Pathways and Functions:** Despite its non-functional nature, TRAJ61 may still play a role in regulating T cell development and function through various pathways. One possible mechanism is through its involvement in the Notch signaling pathway, which is crucial for T cell development and differentiation. The Notch pathway can influence the expression of TRAJ61, potentially modulating T cell fate decisions. Another possible function of TRAJ61 is its involvement in the regulation of T cell homeostasis. As a non-functional gene, TRAJ61 may help maintain the balance between T cell proliferation and apoptosis, ensuring that the immune system operates within a narrow window of tolerance. **Clinical Significance:** The discovery of TRAJ61 has significant implications for our understanding of immune dysfunction and disease. As a non-functional gene, TRAJ61 may contribute to the development of autoimmune diseases, such as multiple sclerosis or type 1 diabetes, where T cell dysfunction plays a critical role. Furthermore, TRAJ61 may also be involved in the pathogenesis of cancer, where T cell exhaustion and dysfunction are common features. The study of TRAJ61 may provide insights into the development of novel therapeutic strategies targeting T cell exhaustion and dysfunction. In conclusion, the TRAJ61 gene is a fascinating example of a non-functional gene that plays a crucial role in T cell development and function. Further research is needed to fully understand the mechanisms underlying TRAJ61 and its clinical significance. As an expert immunologist, it is essential to continue exploring the intricacies of the immune system, shedding light on the mysteries of genes like TRAJ61 and their role in maintaining immune homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.