Gene DEFB106B - ENSG00000187082 | NCBI Gene ID: 503841

Details for: DEFB106B

Gene ID: 503841

Symbol: DEFB106B

Ensembl ID: ENSG00000187082

Description: defensin beta 106B

Associated with

Antimicrobial peptides
(R-HSA-6803157)
Beta defensins
(R-HSA-1461957)
Defensins
(R-HSA-1461973)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Antifungal innate immune response
(GO:0061760)
Ccr2 chemokine receptor binding
(GO:0031727)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to gram-positive bacterium
(GO:0050830)
Heparin binding
(GO:0008201)
Innate immune response
(GO:0045087)
Lipopolysaccharide binding
(GO:0001530)
Membrane
(GO:0016020)
Microvesicle
(GO:1990742)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 5.24
Marker Score: 2192
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 4.49
Marker Score: 2412
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 4.35
Marker Score: 2291
Cell Name: megakaryocyte (CL0000556)
Fold Change: 3.92
Marker Score: 2225
Cell Name: erythrocyte (CL0000232)
Fold Change: 3.85
Marker Score: 2132
Cell Name: mast cell (CL0000097)
Fold Change: 3.37
Marker Score: 1955
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 2.47
Marker Score: 1969
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.38
Marker Score: 2413
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.27
Marker Score: 2411
Cell Name: macrophage (CL0000235)
Fold Change: 2.16
Marker Score: 2406
Cell Name: brush cell (CL0002204)
Fold Change: 1.86
Marker Score: 1699
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.74
Marker Score: 2407
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.16
Marker Score: 2408
Cell Name: goblet cell (CL0000160)
Fold Change: 1.09
Marker Score: 7250
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.97
Marker Score: 1573
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.94
Marker Score: 29141
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2737
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.9
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.81
Marker Score: 4643
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8
Marker Score: 4846
Cell Name: neuron (CL0000540)
Fold Change: 0.59
Marker Score: 2413
Cell Name: progenitor cell (CL0011026)
Fold Change: 0.37
Marker Score: 2363
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.04
Marker Score: 2413

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Other Information

Description

**Key Characteristics** Defensin beta 106B shares structural and functional similarities with other defensins, such as β-defensin 1 and β-defensin 2. These peptides exhibit antimicrobial activity against a range of pathogens, including fungi and bacteria, through mechanisms that include disruption of microbial membranes and induction of pro-inflammatory responses. The defensin beta 106B gene is characterized by its expression in specific cell types, suggesting a specialized role in immune cell development and function. **Pathways and Functions** The pathways and functions of defensin beta 106B are closely related to those of other defensins. These peptides are involved in the antifungal innate immune response, antimicrobial peptides, and defense against gram-negative and gram-positive bacteria. The gene is also implicated in the regulation of immune responses through its interaction with chemokine receptors, such as CCR2, and its ability to bind heparin and lipopolysaccharides. The expression of defensin beta 106B in various cell types, including hematopoietic stem cells and plasmacytoid dendritic cells, suggests its involvement in the development and maturation of immune cells. **Clinical Significance** The clinical significance of defensin beta 106B is not yet fully established. However, its expression in specific cell types and its involvement in immune responses suggest potential roles in the prevention and treatment of infectious diseases. For example, the antimicrobial activity of defensin beta 106B against fungal pathogens may be beneficial in the treatment of fungal infections, such as candidiasis. Additionally, the gene's expression in hematopoietic stem cells and plasmacytoid dendritic cells may be important in the development of immunotherapies targeting the innate immune response. Furthermore, defensin beta 106B may also play a role in the regulation of immune responses in diseases such as asthma and autoimmune disorders. The gene's interaction with chemokine receptors and its ability to induce pro-inflammatory responses suggest that it may be involved in the pathogenesis of these diseases. Further research is needed to fully elucidate the clinical significance of defensin beta 106B and its potential applications in the prevention and treatment of infectious diseases and immune-related disorders. **Implications for Immunology Research** The discovery of defensin beta 106B highlights the importance of antimicrobial peptides in the innate immune response. Further research on this gene and its functions may lead to a better understanding of the mechanisms underlying innate immunity and the development of novel immunotherapies targeting the innate immune response. Additionally, the study of defensin beta 106B may provide insights into the pathogenesis of infectious diseases and immune-related disorders, ultimately leading to the development of more effective treatments and prevention strategies. In conclusion, defensin beta 106B is a fascinating gene that plays a crucial role in the innate immune response. Further research on this gene and its functions may lead to a better understanding of the mechanisms underlying innate immunity and the development of novel immunotherapies targeting the innate immune response.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.