RFWD3 | ENSG00000168411 | NCBI 55159

Details for: RFWD3

Gene ID: 55159

Symbol: RFWD3

Ensembl ID: ENSG00000168411

Description: ring finger and WD repeat domain 3

Associated with

Cytoplasm
(GO:0005737)
Dna damage response
(GO:0006974)
Double-strand break repair via homologous recombination
(GO:0000724)
Interstrand cross-link repair
(GO:0036297)
Mdm2/mdm4 family protein binding
(GO:0097371)
Metal ion binding
(GO:0046872)
Mitotic g1 dna damage checkpoint signaling
(GO:0031571)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Pml body
(GO:0016605)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Regulation of dna damage checkpoint
(GO:2000001)
Replication fork processing
(GO:0031297)
Response to ionizing radiation
(GO:0010212)
Site of dna damage
(GO:0090734)
Site of double-strand break
(GO:0035861)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

RING finger and WD repeat domain-containing protein 3

Genular Protein ID: 952390783

Symbol: RFWD3_HUMAN

Name: RING finger and WD repeat domain-containing protein 3

UniProtKB Accession Codes:

Q6PCD5 A8K585 B2RE35 D3DUJ8 Q5XKR3 Q9H9Q3 Q9NVT4

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20173098

Title: RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.

PubMed ID: 20173098

DOI: 10.1073/pnas.0912094107

PubMed ID: 21504906

Title: E3 ligase RFWD3 participates in replication checkpoint control.

PubMed ID: 21504906

DOI: 10.1074/jbc.m111.222869

PubMed ID: 21558276

Title: RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.

PubMed ID: 21558276

DOI: 10.1074/jbc.m111.222802

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26474068

Title: RFWD3-dependent ubiquitination of RPA regulates repair at stalled replication forks.

PubMed ID: 26474068

DOI: 10.1016/j.molcel.2015.09.011

PubMed ID: 28575657

Title: RPA-mediated recruitment of the E3 ligase RFWD3 is vital for interstrand crosslink repair and human health.

PubMed ID: 28575657

DOI: 10.1016/j.molcel.2017.04.021

PubMed ID: 28691929

Title: Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia.

PubMed ID: 28691929

DOI: 10.1172/jci92069

PubMed ID: 28575658

Title: RFWD3-mediated ubiquitination promotes timely removal of both RPA and RAD51 from dna damage sites to facilitate homologous recombination.

PubMed ID: 28575658

DOI: 10.1016/j.molcel.2017.04.022

Sequence Information:

Length: 774
Mass: 85094
Checksum: EF6E0E186FD2E580
Sequence:

MAHEAMEYDV QVQLNHAEQQ PAPAGMASSQ GGPALLQPVP ADVVSSQGVP SILQPAPAEV 
ISSQATPPLL QPAPQLSVDL TEVEVLGEDT VENINPRTSE QHRQGSDGNH TIPASSLHSM 
TNFISGLQRL HGMLEFLRPS SSNHSVGPMR TRRRVSASRR ARAGGSQRTD SARLRAPLDA 
YFQVSRTQPD LPATTYDSET RNPVSEELQV SSSSDSDSDS SAEYGGVVDQ AEESGAVILE 
EQLAGVSAEQ EVTCIDGGKT LPKQPSPQKS EPLLPSASMD EEEGDTCTIC LEQWTNAGDH 
RLSALRCGHL FGYRCISTWL KGQVRKCPQC NKKARHSDIV VLYARTLRAL DTSEQERMKS 
SLLKEQMLRK QAELESAQCR LQLQVLTDKC TRLQRRVQDL QKLTSHQSQN LQQPRGSQAW 
VLSCSPSSQG QHKHKYHFQK TFTVSQAGNC RIMAYCDALS CLVISQPSPQ ASFLPGFGVK 
MLSTANMKSS QYIPMHGKQI RGLAFSSYLR GLLLSASLDN TIKLTSLETN TVVQTYNAGR 
PVWSCCWCLD EANYIYAGLA NGSILVYDVR NTSSHVQELV AQKARCPLVS LSYMPRAASA 
AFPYGGVLAG TLEDASFWEQ KMDFSHWPHV LPLEPGGCID FQTENSSRHC LVTYRPDKNH 
TTIRSVLMEM SYRLDDTGNP ICSCQPVHTF FGGPTCKLLT KNAIFQSPEN DGNILVCTGD 
EAANSALLWD AASGSLLQDL QTDQPVLDIC PFEVNRNSYL ATLTEKMVHI YKWE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RFWD3

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. PubMed ID: 20173098

E3 ligase RFWD3 participates in replication checkpoint control. PubMed ID: 21504906

RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response. PubMed ID: 21558276

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

RFWD3-dependent ubiquitination of RPA regulates repair at stalled replication forks. PubMed ID: 26474068

RPA-mediated recruitment of the E3 ligase RFWD3 is vital for interstrand crosslink repair and human health. PubMed ID: 28575657

Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia. PubMed ID: 28691929

RFWD3-mediated ubiquitination promotes timely removal of both RPA and RAD51 from dna damage sites to facilitate homologous recombination. PubMed ID: 28575658