Details for: TSPY1

Gene ID: 7258

Symbol: TSPY1

Ensembl ID: ENSG00000258992

Description: testis specific protein Y-linked 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: male germ cell (CL0000015)
    Fold Change: 3.43
    Marker Score: 988
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.37
    Marker Score: 1573
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.14
    Marker Score: 3692
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.65
    Marker Score: 1844
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1221
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.24
    Marker Score: 721
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.15
    Marker Score: 1221
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7304
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.07
    Marker Score: 1191
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.96
    Marker Score: 29762
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.96
    Marker Score: 762
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.93
    Marker Score: 2376
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.93
    Marker Score: 834
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.88
    Marker Score: 1102
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.87
    Marker Score: 2613
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.85
    Marker Score: 1215
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1337
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.82
    Marker Score: 745
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4648
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.81
    Marker Score: 4906
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1206
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 709
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.72
    Marker Score: 1219
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.7
    Marker Score: 1216
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.59
    Marker Score: 1222
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.52
    Marker Score: 1224
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.46
    Marker Score: 1222
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.4
    Marker Score: 1224
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.37
    Marker Score: 1269
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.21
    Marker Score: 1218

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Other Information

**Key Characteristics** TSPY1 is a Y-linked gene, meaning it is located on the Y chromosome and is exclusively expressed in males. The gene encodes a protein that is involved in the regulation of sex-specific gene expression, particularly in the development of male germ cells. The protein has been shown to interact with various cellular components, including chromatin, histones, and other proteins, highlighting its role in the regulation of gene expression. **Pathways and Functions** TSPY1 has been implicated in various cellular pathways, including: 1. **Sex Differentiation**: TSPY1 plays a crucial role in the regulation of sex-specific gene expression, particularly in the development of male germ cells. The gene is essential for the expression of male-specific genes, such as SRY (sex-determining region Y) and SOX9, which are critical for male sex determination. 2. **Spermatogenesis**: TSPY1 is essential for the development of male germ cells, particularly in the process of spermatogenesis. The gene regulates the expression of genes involved in the development of sperm cells, including genes involved in histone modification and chromatin assembly. 3. **Cell Differentiation**: TSPY1 regulates the differentiation of male germ cells into spermatogonia, spermatocytes, and spermatozoa. The gene interacts with various cellular components, including chromatin and histones, to regulate the expression of genes involved in cell differentiation. **Clinical Significance** The clinical significance of TSPY1 is significant, particularly in the context of male infertility. Studies have shown that mutations in the TSPY1 gene can lead to male infertility, highlighting the importance of the gene in spermatogenesis. Additionally, TSPY1 has been implicated in various immune-related disorders, including autoimmune diseases and immunodeficiency disorders. The gene's role in regulating sex-specific gene expression has also raised interest in its potential as a therapeutic target for the treatment of sex-related disorders. In conclusion, TSPY1 is a critical gene involved in the regulation of sex-specific gene expression, particularly in the development of male germ cells. Its role in spermatogenesis, cell differentiation, and histone binding highlights its significance in the regulation of gene expression. The clinical significance of TSPY1 is significant, particularly in the context of male infertility and immune-related disorders. Further research is needed to fully understand the role of TSPY1 in human health and disease.

Genular Protein ID: 2946464421

Symbol: A4FUW6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A4FUW6

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 HOGENOM 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 221
  • Mass: 25910
  • Checksum: D14AB4CDB80426FC
  • Sequence:
    • MRPEGSLTYR VPERLRQGFC GVGRAAQALV ELEPVNAQAR KAFSRQREKM ERRRKPHLDR 
RGAVIQSVPG FWANVIANHP QMSALITDED EDMLSYMVSL EVGEEKHPVH LCKIMLFFRS 
NPYFQNKVIT KEYLVNITEY RASHSTPIEW YPDYEVEAYR RRHHNSSLNF FNWFSDHNFA 
GSNKIAEILC KDLWRNPLQY YKRMKPPEEG TETSGDSQLL S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.