Details for: H4C7

Gene ID: 8369

Symbol: H4C7

Ensembl ID: ENSG00000275663

Description: H4 clustered histone 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0678
    Cell Significance Index: 0.6700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0122
    Cell Significance Index: 0.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0004
    Cell Significance Index: 0.0000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0026
    Cell Significance Index: -0.0200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0769
    Cell Significance Index: -0.9200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1099
    Cell Significance Index: -1.4300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1133
    Cell Significance Index: -1.3000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1137
    Cell Significance Index: -2.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1837
    Cell Significance Index: -3.6600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1962
    Cell Significance Index: -2.1900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2004
    Cell Significance Index: -2.1500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2005
    Cell Significance Index: -2.0500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2154
    Cell Significance Index: -2.0100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2227
    Cell Significance Index: -2.7400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2302
    Cell Significance Index: -2.3500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2331
    Cell Significance Index: -1.9900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2350
    Cell Significance Index: -2.7800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2362
    Cell Significance Index: -2.7800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2390
    Cell Significance Index: -2.8700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2405
    Cell Significance Index: -2.6600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2549
    Cell Significance Index: -2.7100
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2823
    Cell Significance Index: -1.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2918
    Cell Significance Index: -4.1800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3274
    Cell Significance Index: -1.9400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4836
    Cell Significance Index: -4.2600
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.5383
    Cell Significance Index: -2.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The H4C7 gene belongs to the histone family, which is a group of highly conserved proteins that play a crucial role in chromatin structure and gene regulation. Histones are composed of two identical copies of a histone protein, with the H4C7 gene encoding a histone-like protein. The H4C7 protein is part of the nucleosome assembly, a fundamental component of chromatin, and is involved in DNA binding, protein binding, and protein heterodimerization. The expression of H4C7 is tissue-specific, with high levels detected in pericytes, stromal cells, and kidney epithelial cells, suggesting its involvement in tissue-specific gene regulation. **Pathways and Functions:** The H4C7 gene is involved in several key pathways, including: 1. **DNA Binding:** H4C7 binds to DNA, facilitating the recruitment of transcription factors and other regulatory proteins to specific genomic regions. 2. **Nucleosome Assembly:** H4C7 is a component of the nucleosome assembly, which is the fundamental unit of chromatin structure. 3. **Protein Binding:** H4C7 interacts with other proteins, including histone-modifying enzymes, to regulate chromatin structure and gene expression. 4. **Protein Heterodimerization:** H4C7 forms heterodimers with other histone proteins, such as H3, to regulate chromatin structure and function. The functions of H4C7 are multifaceted, including: 1. **Chromatin Regulation:** H4C7 regulates chromatin structure and gene expression by recruiting transcription factors and other regulatory proteins to specific genomic regions. 2. **Cellular Homeostasis:** H4C7 maintains cellular homeostasis by regulating gene expression in response to environmental changes. 3. **Tissue-Specific Gene Regulation:** H4C7 is involved in tissue-specific gene regulation, with high levels detected in kidney epithelial cells and pericytes. **Clinical Significance:** The H4C7 gene has significant clinical implications, particularly in the context of kidney disease. Alterations in H4C7 expression have been linked to various kidney disorders, including nephrotic syndrome and chronic kidney disease. Furthermore, H4C7 has been implicated in the regulation of gene expression in response to environmental toxins, suggesting its potential role in the development of toxicities. In conclusion, the H4C7 gene is a critical component of chromatin regulation and cellular function, with significant implications for our understanding of kidney disease and cellular homeostasis. Further research is needed to fully elucidate the functions of H4C7 and its role in human disease.

Genular Protein ID: 537970637

Symbol: H4G_HUMAN

Name: Histone H4-like protein type G

UniProtKB Accession Codes:

Q99525

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9119399

Title: Human histone gene organization: nonregular arrangement within a large cluster.

PubMed ID: 9119399

DOI: 10.1006/geno.1996.4592

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 98
  • Mass: 11009
  • Checksum: B76078AC96AE4DEB
  • Sequence:
    • MSVRGKAGKG LGKGGAKCHR KVLSDNIQGI TKCTIRRLAR HGGVKRILGL IYEETRRVFK 
VFLENVIWYA VTNTEHAKRK TVTAMAVVYV LKRQGRTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.