Details for: DEFB115

Gene ID: 245929

Symbol: DEFB115

Ensembl ID: ENSG00000215547

Description: defensin beta 115

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0456
    Cell Significance Index: 0.5200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0241
    Cell Significance Index: 0.2600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0138
    Cell Significance Index: 0.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0011
    Cell Significance Index: 0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0002
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0035
    Cell Significance Index: -0.7000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0079
    Cell Significance Index: -0.0500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0088
    Cell Significance Index: -0.0800
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0112
    Cell Significance Index: -0.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0120
    Cell Significance Index: -0.2600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0128
    Cell Significance Index: -0.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0150
    Cell Significance Index: -0.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0158
    Cell Significance Index: -0.1700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0172
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0206
    Cell Significance Index: -0.2700
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0218
    Cell Significance Index: -0.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0223
    Cell Significance Index: -0.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0266
    Cell Significance Index: -0.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0319
    Cell Significance Index: -0.6800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0405
    Cell Significance Index: -0.5100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0424
    Cell Significance Index: -0.4500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0543
    Cell Significance Index: -0.7300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0603
    Cell Significance Index: -0.7400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0619
    Cell Significance Index: -0.8300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0624
    Cell Significance Index: -0.8300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0740
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0891
    Cell Significance Index: -0.8400
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.1097
    Cell Significance Index: -0.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DB115 is a 37-amino acid peptide, belonging to the beta-defensin subfamily. Its expression is restricted to specific cell types, including connective tissue cells, renal cells, and lymphoid lineage progenitor cells. This restricted expression suggests a specialized function in the innate immune response. DB115 exhibits a unique ability to bind to proteins and other molecules, which may facilitate its interaction with target cells and pathogens. **Pathways and Functions:** DB115 is involved in several key pathways, including: 1. **Antimicrobial peptides:** DB115 exhibits potent antimicrobial activity against a range of bacteria, including Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Its mechanism of action is thought to involve disruption of bacterial membranes and inhibition of protein synthesis. 2. **Defense response to bacterium:** DB115 is induced in response to bacterial infections and plays a crucial role in the innate immune response. It interacts with pattern recognition receptors, such as Toll-like receptors, to activate signaling pathways that lead to the production of pro-inflammatory cytokines. 3. **Innate immune response:** DB115 is involved in the regulation of the innate immune response, including the activation of immune cells, such as macrophages and neutrophils, and the production of anti-inflammatory cytokines. **Clinical Significance:** DB115 has been implicated in various human diseases, including: 1. **Inflammatory bowel disease (IBD):** DB115 expression is altered in patients with IBD, suggesting a potential role in the pathogenesis of this disease. 2. **Cystic fibrosis:** DB115 has been shown to have antimicrobial activity against Pseudomonas aeruginosa, a common pathogen in cystic fibrosis patients. 3. **Renal disease:** DB115 is expressed in renal cells and may play a role in the regulation of renal function and the response to infection. In conclusion, DB115 is a novel antimicrobial peptide that plays a critical role in the innate immune response against bacterial infections. Its unique characteristics and functions suggest a potential therapeutic application in the treatment of human diseases, including IBD, cystic fibrosis, and renal disease. Further research is needed to fully elucidate the mechanisms of DB115 and its clinical significance in human disease.

Genular Protein ID: 4060157902

Symbol: DB115_HUMAN

Name: Beta-defensin 115

UniProtKB Accession Codes:

Q30KQ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 GO 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16033865

Title: Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.

PubMed ID: 16033865

DOI: 10.1152/physiolgenomics.00104.2005

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

Sequence Information:

  • Length: 88
  • Mass: 10071
  • Checksum: 9E4437B69A9121CC
  • Sequence:
    • MLPDHFSPLS GDIKLSVLAL VVLVVLAQTA PDGWIRRCYY GTGRCRKSCK EIERKKEKCG 
EKHICCVPKE KDKLSHIHDQ KETSELYI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.